{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:50:31Z","timestamp":1793116231216,"version":"4.5.0"},"reference-count":48,"publisher":"American Society for Clinical Investigation","issue":"15","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH and AHA","award":["HL-144477,AI142037,HL125780,AI056234,19POST34430075\/2019"],"award-info":[{"award-number":["HL-144477,AI142037,HL125780,AI056234,19POST34430075\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,9]]},"abstract":"<jats:p>\n                    The stimulator of IFN genes (STING) protein senses cyclic dinucleotides released in response to double-stranded DNA and functions as an adaptor molecule for type I IFN (IFNI) signaling by activating IFNI-stimulated genes (ISG). We found impaired T cell infiltration into the peritoneum in response to TNF-\n                    <jats:bold>\u03b1<\/jats:bold>\n                    in global and EC-specific STING\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice and discovered that T cell transendothelial migration (TEM) across mouse and human endothelial cells (EC) deficient in STING was strikingly reduced compared with control EC, whereas T cell adhesion was not impaired. STING\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    T cells showed no defect in TEM or adhesion to EC, or immobilized endothelial cell\u2013expressed molecules ICAM1 and VCAM1, compared with WT T cells. Mechanistically, CXCL10, an ISG and a chemoattractant for T cells, was dramatically reduced in TNF-\n                    <jats:bold>\u03b1<\/jats:bold>\n                    \u2013stimulated STING\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    EC, and genetic loss or pharmacologic antagonisms of IFNI receptor (IFNAR) pathway reduced T cell TEM. Our data demonstrate a central role for EC-STING during T cell TEM that is dependent on the ISG CXCL10 and on IFNI\/IFNAR signaling.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.149346","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T12:03:48Z","timestamp":1624363428000},"source":"Crossref","is-referenced-by-count":45,"title":["Endothelial STING controls T cell transmigration in an IFNI-dependent manner"],"prefix":"10.1172","volume":"6","author":[{"given":"Marina","family":"Anastasiou","sequence":"first","affiliation":[{"name":"Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, USA."},{"name":"Department of Internal Medicine, University of Crete Medical School, Crete, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail A.","family":"Newton","sequence":"additional","affiliation":[{"name":"Center for Excellence in Vascular Biology, Department of Pathology, Brigham and 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