{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:30:19Z","timestamp":1793212219554,"version":"4.5.0"},"reference-count":70,"publisher":"American Society for Clinical Investigation","issue":"3","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health Grant","doi-asserted-by":"crossref","award":["R01 HL130324,AI125445,R01 HL133900"],"award-info":[{"award-number":["R01 HL130324,AI125445,R01 HL133900"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"German Research Foundation Grant","award":["CO 2096\/1-1,BA1606\/3-1,BA1606\/4-1,ZA428\/14-1,KFO342,DR1013\/1-1,KFO309,SFB\/TR-84"],"award-info":[{"award-number":["CO 2096\/1-1,BA1606\/3-1,BA1606\/4-1,ZA428\/14-1,KFO342,DR1013\/1-1,KFO309,SFB\/TR-84"]}]},{"name":"Interdisciplinary Center for Clinical Research Grant","award":["Za2\/001\/18,SEED12\/18"],"award-info":[{"award-number":["Za2\/001\/18,SEED12\/18"]}]},{"DOI":"10.13039\/501100003495","name":"Hessisches Ministerium f\u00fcr Wissenschaft und Kunst","doi-asserted-by":"crossref","award":["LOEWE Diffusible Signals"],"award-info":[{"award-number":["LOEWE Diffusible Signals"]}],"id":[{"id":"10.13039\/501100003495","id-type":"DOI","asserted-by":"crossref"}]},{"name":"German Federal Ministry of Education and Research (BMBF) Grant","award":["ERACoSysMed2 \u2013 SysMed-COPD \u2013 FKZ 031L0140"],"award-info":[{"award-number":["ERACoSysMed2 \u2013 SysMed-COPD \u2013 FKZ 031L0140"]}]},{"name":"German Federal Ministry of Education and Research (BMBF) Grant","award":["e:Med CAPSYS \u2013 FKZ  01ZX1604E"],"award-info":[{"award-number":["e:Med CAPSYS \u2013 FKZ  01ZX1604E"]}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation Grant","doi-asserted-by":"crossref","award":["CHE-1904865"],"award-info":[{"award-number":["CHE-1904865"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008984","name":"International Anesthesia Research Society","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100008984","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,8]]},"abstract":"<jats:p>\n                    Acute respiratory distress syndrome (ARDS) results in catastrophic lung failure and has an urgent, unmet need for improved early recognition and therapeutic development. Neutrophil influx is a hallmark of ARDS and is associated with the release of tissue-destructive immune effectors, such as matrix metalloproteinases (MMPs) and membrane-anchored metalloproteinase disintegrins (ADAMs). Here, we observed using intravital microscopy that\n                    <jats:italic>\n                      Adam8\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice had impaired neutrophil transmigration. In mouse pneumonia models, both genetic deletion and pharmacologic inhibition of ADAM8 attenuated neutrophil infiltration and lung injury while improving bacterial containment. Unexpectedly, the alterations of neutrophil function were not attributable to impaired proteolysis but resulted from reduced intracellular interactions of ADAM8 with the actin-based motor molecule Myosin1f that suppressed neutrophil motility. In 2 ARDS cohorts, we analyzed lung fluid proteolytic signatures and identified that ADAM8 activity was positively correlated with disease severity. We propose that in acute inflammatory lung diseases such as pneumonia and ARDS, ADAM8 inhibition might allow fine-tuning of neutrophil responses for therapeutic gain.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.149870","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T14:00:56Z","timestamp":1644242456000},"source":"Crossref","is-referenced-by-count":52,"title":["ADAM8 signaling drives neutrophil migration and ARDS severity"],"prefix":"10.1172","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7160-9169","authenticated-orcid":true,"given":"Catharina","family":"Conrad","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, School of Medicine, University of California, San Francisco, San Francisco, California, USA."},{"name":"Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology, PZMS, ZHMB, Saarland University, Homburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5573-6363","authenticated-orcid":true,"given":"Simon J.","family":"Cleary","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, School of Medicine, University of California, San Francisco, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6539-6478","authenticated-orcid":true,"given":"Andreas","family":"Margraf","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5010-7987","authenticated-orcid":true,"given":"Lena","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery\/Lab, Faculty of Medicine, Philipps-University, Marburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Schlomann","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery\/Lab, Faculty of Medicine, Philipps-University, Marburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7377-4547","authenticated-orcid":true,"given":"Barry","family":"Panaretou","sequence":"additional","affiliation":[{"name":"School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King\u2019s College London, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Bowser","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4753-9823","authenticated-orcid":true,"given":"Harry","family":"Karmouty-Quintana","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8595-860X","authenticated-orcid":true,"given":"Jiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2568-2867","authenticated-orcid":true,"given":"Nathaniel K.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1866-2008","authenticated-orcid":true,"given":"Samuel C.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Rice University, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0982-3583","authenticated-orcid":true,"given":"Ahmad","family":"Aljohmani","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology, PZMS, ZHMB, Saarland University, Homburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Farshid","family":"Moussavi-Harami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Critical Care, University of California, San Francisco, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-9900","authenticated-orcid":true,"given":"Kristin M.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, School of Medicine, University of California, San Francisco, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3850-439X","authenticated-orcid":true,"given":"Jennifer J.","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, School of Medicine, University of California, San Francisco, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lia","family":"Magnen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, School of Medicine, University of California, San Francisco, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Valet","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, School of Medicine, University of California, San Francisco, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3122-9679","authenticated-orcid":true,"given":"Longhui","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, School of Medicine, University of California, San Francisco, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-7472","authenticated-orcid":true,"given":"Jonathan P.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, School of Medicine, University of California, San Francisco, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger K.","family":"Eltzschig","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CAPSys Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0180-2529","authenticated-orcid":true,"given":"Wilhelm","family":"Bertrams","sequence":"additional","affiliation":[{"name":"Institute for Lung Research (iLung), Philipps-University, Marburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Herold","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Medical Center Giessen and Marburg, Giessen, Germany."},{"name":"Deutsches Zentrum f\u00fcr Lungenforschung (DZL), Giessen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Suttorp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Infectious Diseases and Respiratory Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2767-3606","authenticated-orcid":true,"given":"Bernd","family":"Schmeck","sequence":"additional","affiliation":[{"name":"Deutsches Zentrum f\u00fcr Lungenforschung (DZL), Giessen, Germany."},{"name":"Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Marburg, Germany."},{"name":"German Center for Infectious Disease Research (DZIF), Marburg, Germany."},{"name":"Center for Synthetic Microbiology (SYNMIKRO), Marburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-0789","authenticated-orcid":true,"given":"Zachary T.","family":"Ball","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Rice University, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zarbock","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital M\u00fcnster, M\u00fcnster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-9190","authenticated-orcid":true,"given":"Mark R.","family":"Looney","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, School of Medicine, University of California, San Francisco, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg W.","family":"Bartsch","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery\/Lab, Faculty of Medicine, Philipps-University, Marburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1608077"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0291"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050333"},{"issue":"2 pt 1","key":"B4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1164\/ajrccm.151.2.7842182","article-title":"Clinical risks for development of the acute respiratory distress syndrome","volume":"151","author":"Hudson","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201609-1773CP"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062200"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214103"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005372"},{"issue":"10","key":"B9","article-title":"Ventilator-induced lung injury","volume":"370","author":"Slutsky","year":"2014","journal-title":"N Engl J Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30188-1"},{"key":"B12","unstructured":"WHO. Weekly epidemiological update on COVID-19 - 28 December 2021. https:\/\/www.who.int\/publications\/m\/item\/weekly-epidemiological-update-on-covid-19---28-december-2021 Accessed January 5, 2022"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.11825"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1401520"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051693"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-2778-x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-209170"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004651"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124616"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.1.8025736"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nri1418"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0068-5"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00146510"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.11.023"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201804-0678OC"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.8053"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.07.006"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.02.002"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1042\/CS20180906"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4607"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203355200"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7175"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20080145"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-010-0591-8"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141764"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M213157200"},{"issue":"3","key":"B38","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1515\/BC.2006.045","article-title":"Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8","volume":"387","author":"Naus","year":"2006","journal-title":"Biol Chem"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121301"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0069-0"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00444.2016"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1396OC"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02739"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1159\/000345943"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1543"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-10-811851"},{"key":"B47","article-title":"Intermittent rolling is a defect of the extravasation cascade caused by Myosin1e-deficiency in neutrophils","author":"Vadillo","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201303373"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.9b00309"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182939831"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1039\/C0IB00083C"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2007.04.043"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.07.021"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.1MR0918-350RRR"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131920"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09104-1"},{"issue":"3","key":"B57","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/srep30451"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.020"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202329"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-21-07964.2000"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20221"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70097-9"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.04.011"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/nature16985"},{"issue":"77","key":"B66","doi-asserted-by":"crossref","DOI":"10.3791\/50586-v","article-title":"Isolation, purification and labeling of mouse bone marrow neutrophils for functional studies and adoptive transfer experiments","author":"Swamydas","year":"2013","journal-title":"J Vis Exp"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1172\/JCI138136"},{"key":"B68","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-1-4939-8712-2_11","article-title":"Imaging lymphatics in mouse lungs","volume":"1846","author":"Baluk","year":"2018","journal-title":"Methods Mol Biol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0145OC"},{"key":"B70","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-6850-3_18","article-title":"Simultaneous detection of metalloprotease activities in complex biological samples using the PrAMA (proteolytic activity matrix assay) method","volume":"1574","author":"Conrad","year":"2017","journal-title":"Methods Mol Biol"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/149870\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:38:36Z","timestamp":1779147516000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/149870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,8]]},"references-count":70,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,2,8]]},"published-print":{"date-parts":[[2022,2,8]]}},"alternative-id":["10.1172\/jci.insight.149870"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.149870","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,8]]},"article-number":"e149870"}}