{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:44:26Z","timestamp":1792172666640,"version":"4.4.0"},"reference-count":59,"publisher":"American Society for Clinical Investigation","issue":"23","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01-HL111449,T32-HL007035,F32-HL147461,R35-HL135756,F31-HL147397,K08-HL130582,R01-HL136725"],"award-info":[{"award-number":["R01-HL111449,T32-HL007035,F32-HL147461,R35-HL135756,F31-HL147397,K08-HL130582,R01-HL136725"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["R01-GM120060"],"award-info":[{"award-number":["R01-GM120060"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R01-AI115053"],"award-info":[{"award-number":["R01-AI115053"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["K99-HL159258,R56-HL165718"],"award-info":[{"award-number":["K99-HL159258,R56-HL165718"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,8]]},"abstract":"<jats:p>\n                    Identifying host factors that contribute to pneumonia incidence and severity are of utmost importance to guiding the development of more effective therapies. Lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1, encoded by\n                    <jats:italic>OLR1<\/jats:italic>\n                    ) is a scavenger receptor known to promote vascular injury and inflammation, but whether and how LOX-1 functions in the lung are unknown. Here, we provide evidence of substantial accumulation of LOX-1 in the lungs of patients with acute respiratory distress syndrome and in mice with pneumonia. Unlike previously described injurious contributions of LOX-1, we found that LOX-1 is uniquely protective in the pulmonary airspaces, limiting proteinaceous edema and inflammation. We also identified alveolar macrophages and recruited neutrophils as 2 prominent sites of LOX-1 expression in the lungs, whereby macrophages are capable of further induction during pneumonia and neutrophils exhibit a rapid, but heterogenous, elevation of LOX-1 in the infected lung. Blockade of LOX-1 led to dysregulated immune signaling in alveolar macrophages, marked by alterations in activation markers and a concomitant elevation of inflammatory gene networks. However, bone marrow chimeras also suggested a prominent role for neutrophils in LOX-1\u2013mediated lung protection, further supported by LOX-1\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils exhibiting transcriptional changes consistent with reparative processes. Taken together, this work establishes LOX-1 as a tissue-protective factor in the lungs during pneumonia, possibly mediated by its influence on immune signaling in alveolar macrophages and LOX-1\n                    <jats:sup>+<\/jats:sup>\n                    airspace neutrophils.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.149955","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T12:01:17Z","timestamp":1666267277000},"source":"Crossref","is-referenced-by-count":20,"title":["Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury"],"prefix":"10.1172","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1158-7164","authenticated-orcid":true,"given":"Filiz T.","family":"Korkmaz","sequence":"first","affiliation":[{"name":"Division of Immunology and Infectious Disease, Department of Medicine, UMass Chan Medical School, Worcester, Massachusetts, 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