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I\u03baB kinase \u03b2 (IKK-\u03b2), a central coordinator of inflammation through activation of NF-\u03baB, has been demonstrated as a key molecular link between inflammation and cardiovascular disease. However, the cell-specific contribution of IKK-\u03b2 signaling toward adverse cardiac remodeling remains elusive. Cardiac fibroblasts are one of the most populous nonmyocyte cell types in the heart that play a key role in mediating cardiac fibrosis and remodeling. To investigate the function of fibroblast IKK-\u03b2, we generated inducible fibroblast-specific IKK-\u03b2\u2013deficient mice. Here, we report an important role of IKK-\u03b2 in the regulation of fibroblast functions and cardiac remodeling. Fibroblast-specific IKK-\u03b2\u2013deficient male mice were protected from angiotensin II\u2013induced cardiac hypertrophy, fibrosis, and macrophage infiltration. Ablation of fibroblast IKK-\u03b2 inhibited angiotensin II\u2013stimulated fibroblast proinflammatory and profibrogenic responses, leading to ameliorated cardiac remodeling and improved cardiac function in IKK-\u03b2\u2013deficient mice. Findings from this study establish fibroblast IKK-\u03b2 as a key factor regulating cardiac fibrosis and function in hypertension-related cardiac remodeling.<\/jats:p>","DOI":"10.1172\/jci.insight.150161","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T12:01:59Z","timestamp":1627560119000},"source":"Crossref","is-referenced-by-count":20,"title":["Fibroblast-specific IKK-\u03b2 deficiency ameliorates angiotensin II\u2013induced adverse cardiac remodeling in mice"],"prefix":"10.1172","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-390X","authenticated-orcid":true,"given":"Weiwei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojie","family":"Meng","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, 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