{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:42:57Z","timestamp":1792788177709,"version":"4.5.0"},"reference-count":48,"publisher":"American Society for Clinical Investigation","issue":"13","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81602751,81673052,81872522,82073429"],"award-info":[{"award-number":["81602751,81673052,81872522,82073429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["22120210566"],"award-info":[{"award-number":["22120210566"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Innovation Program of Shanghai Municipal Education Commission","award":["2019-01-07-00-07-E00046"],"award-info":[{"award-number":["2019-01-07-00-07-E00046"]}]},{"name":"the Program of Science and Technology Commission of Shanghai Municipality","award":["18140901800"],"award-info":[{"award-number":["18140901800"]}]},{"name":"Excellent Subject Leader Program of Shanghai Municipal Commission of Health and Family Planning","award":["2018BR30"],"award-info":[{"award-number":["2018BR30"]}]},{"name":"Clinical Research Plan of SHDC","award":["SHDC2020CR1014B,SHDC12018X06"],"award-info":[{"award-number":["SHDC2020CR1014B,SHDC12018X06"]}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"crossref","award":["20XD1403300"],"award-info":[{"award-number":["20XD1403300"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,8]]},"abstract":"<jats:p>Psoriasis is a chronic, inflammatory skin disease, frequently associated with dyslipidemia. Lipid disturbance in psoriasis affects both circulatory system and cutaneous tissue. Epidermal Langerhans cells (LCs) are tissue-resident DCs that maintain skin immune surveillance and mediate various cutaneous disorders, including psoriasis. However, the role of LCs in psoriasis development and their lipid metabolic alternation remains unclear. Here, we demonstrate that epidermal LCs of psoriasis patients enlarge with longer dendrites and possess elevated IL-23p19 mRNA and a higher level of neutral lipids when compared with normal LCs of healthy individuals. Accordantly, epidermal LCs from imiquimod-induced psoriasis-like dermatitis in mice display overmaturation, enhanced phagocytosis, and excessive secretion of IL-23. Remarkably, these altered immune properties in lesional LCs are tightly correlated with elevated neutral lipid levels. Moreover, the increased lipid content of psoriatic LCs might result from impaired autophagy of lipids. Bulk RNA-Seq analysis identifies dysregulated genes involved in lipid metabolism, autophagy, and immunofunctions in murine LCs. Overall, our data suggest that dysregulated lipid metabolism influences LC immunofunction, which contributes to the development of psoriasis, and therapeutic manipulation of this metabolic process might provide an effective measurement for psoriasis.<\/jats:p>","DOI":"10.1172\/jci.insight.150223","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T14:00:56Z","timestamp":1657202456000},"source":"Crossref","is-referenced-by-count":48,"title":["Abnormal lipid metabolism in epidermal Langerhans cells mediates psoriasis-like dermatitis"],"prefix":"10.1172","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5204-4086","authenticated-orcid":true,"given":"Xilin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Shanghai Skin Disease Hospital, School of Medicine, and"},{"name":"Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China."},{"name":"Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Skin Disease Hospital, School of Medicine, and"},{"name":"Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8837-9833","authenticated-orcid":true,"given":"Youdong","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China."},{"name":"Department of Dermatology, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Skin Disease Hospital, School of Medicine, and"},{"name":"Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9849-0340","authenticated-orcid":true,"given":"Zengyang","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China."},{"name":"Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5399-4227","authenticated-orcid":true,"given":"Peng","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China."},{"name":"Department of Dermatology, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfeng","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Skin Disease Hospital, School of Medicine, and"},{"name":"Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1411-6827","authenticated-orcid":true,"given":"Qing-Sheng","family":"Mi","sequence":"additional","affiliation":[{"name":"Center for Cutaneous Biology and Immunology, Department of Dermatology, and"},{"name":"Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Gu","sequence":"additional","affiliation":[{"name":"Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China."},{"name":"Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai, China."},{"name":"Department of Dermatology, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Skin Disease Hospital, School of Medicine, and"},{"name":"Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80160-0"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8470-y"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.08.437"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184347"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8668-1"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.06.057"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2018.11.007"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.05.016"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.12.011"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.033"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.98"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.12.003"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2018.04.003"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201404114"},{"issue":"12","key":"B15","article-title":"Psoriasis and metabolic syndrome: comorbidities and environmental and therapeutic implications","volume":"11","author":"Peralta","year":"2019","journal-title":"Cureus"},{"key":"B16","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/535612","article-title":"Lipid disturbances in psoriasis: an update","volume":"2010","author":"Pietrzak","year":"2010","journal-title":"Mediators Inflamm"},{"key":"B17","first-page":"41","article-title":"The role of the low energy diet in psoriasis vulgaris treatment","volume":"27 Suppl 1","author":"Rucevic","year":"2003","journal-title":"Coll Antropol"},{"issue":"8","key":"B18","first-page":"22","article-title":"[Variability of quantitative changes in short-chain fatty acids in serum and epidermis in psoriasis]","author":"Khyshiktuev","year":"2008","journal-title":"Klin Lab Diagn"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.11.009"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/cia2.12039"},{"key":"B21","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8717369","article-title":"Combined transcriptomic analysis revealed AKR1B10 played an important role in psoriasis through the dysregulated lipid pathway and overproliferation of keratinocyte","volume":"2017","author":"Gao","year":"2017","journal-title":"Biomed Res Int"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2172"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.003"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/srep09613"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2019.03.018"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1319544"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13581"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.08.001"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.6.12510"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052367"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12960"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16172"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00300"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aao1685"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02181.x"},{"key":"B36","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5708239","article-title":"Lipid accumulation in peripheral blood dendritic cells and anticancer immunity in patients with lung cancer","volume":"2018","author":"Arai","year":"2018","journal-title":"J Immunol Res"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.005"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M054874"},{"key":"B39","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1194\/jlr.R800085-JLR200","article-title":"Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways","volume":"50 Suppl","author":"Goldberg","year":"2009","journal-title":"J Lipid Res"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2589"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.514646"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.342"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06461-3"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02186-9"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0373-3"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.06.022"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160258"},{"key":"B48","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2015.00001","article-title":"Macropinocytosis in phagocytes: regulation of MHC class-II-restricted antigen presentation in dendritic cells","volume":"6","author":"Liu","year":"2015","journal-title":"Front Physiol"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/150223\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:32:24Z","timestamp":1779147144000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/150223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,8]]},"references-count":48,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7,8]]},"published-print":{"date-parts":[[2022,7,8]]}},"alternative-id":["10.1172\/jci.insight.150223"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.150223","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,8]]},"article-number":"e150223"}}