{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:27:16Z","timestamp":1791959236399,"version":"4.3.4"},"reference-count":77,"publisher":"American Society for Clinical Investigation","issue":"22","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,22]]},"abstract":"<jats:p>\n                    To determine the mechanisms that mediate resistance to\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    ) infection in household contacts (HHCs) of patients with tuberculosis (TB), we followed 452 latent TB infection\u2013negative (LTBI\n                    <jats:sup>\u2013<\/jats:sup>\n                    ) HHCs for 2 years. Those who remained LTBI\n                    <jats:sup>\u2013<\/jats:sup>\n                    throughout the study were identified as nonconverters. At baseline, nonconverters had a higher percentage of CD14\n                    <jats:sup>+<\/jats:sup>\n                    and CD3\n                    <jats:sup>\u2013<\/jats:sup>\n                    CD56\n                    <jats:sup>+<\/jats:sup>\n                    CD27\n                    <jats:sup>+<\/jats:sup>\n                    CCR7\n                    <jats:sup>+<\/jats:sup>\n                    memory-like natural killer (NK) cells. Using a whole-transcriptome and metabolomic approach, we identified deoxycorticosterone acetate as a metabolite with elevated concentrations in the plasma of nonconverters, and further studies showed that this metabolite enhanced glycolytic ATP flux in macrophages and restricted\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    growth by enhancing antimicrobial peptide production through the expression of the surface receptor sialic acid binding Ig-like lectin\u201314. Another metabolite, 4-hydroxypyridine, from the plasma of nonconverters significantly enhanced the expansion of memory-like NK cells. Our findings demonstrate that increased levels of specific metabolites can regulate innate resistance against\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    infection in HHCs of patients with TB who never develop LTBI or active TB.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.152357","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T14:01:06Z","timestamp":1669039266000},"source":"Crossref","is-referenced-by-count":10,"title":["Metabolites enhance innate resistance to human Mycobacterium tuberculosis infection"],"prefix":"10.1172","volume":"7","author":[{"given":"Deepak","family":"Tripathi","sequence":"first","affiliation":[{"name":"Department of Pulmonary Immunology and Center for Biomedical Research, School of Community and Rural Health, University of Texas Health Science Center, Tyler, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamakshi 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