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In addition, the specific innate sensors driving pathogenic activation of CD1c\n                    <jats:sup>+<\/jats:sup>\n                    cDC in patients with RA and their functional implications have not been characterized. Here, we assessed phenotypical, transcriptional, and functional characteristics of CD1c\n                    <jats:sup>+<\/jats:sup>\n                    and CD141\n                    <jats:sup>+<\/jats:sup>\n                    cDC and monocytes from the blood and synovial fluid of patients with RA. Increased levels of CCR2 and the IgG receptor CD64 on circulating CD1c\n                    <jats:sup>+<\/jats:sup>\n                    cDC was associated with the presence of this DC subset in the synovial membrane in patients with RA. Moreover, synovial CD1c\n                    <jats:sup>+<\/jats:sup>\n                    cDC are characterized by increased expression of proinflammatory cytokines and high abilities to induce pathogenic IFN-\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    IL-17\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells in vitro. Finally, we identified the crosstalk between Fc\u03b3 receptors and NLRC4 as a potential molecular mechanism mediating pathogenic activation, CD64 upregulation, and functional specialization of CD1c\n                    <jats:sup>+<\/jats:sup>\n                    cDC in response to dsDNA-IgG in patients with RA.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.152886","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T12:00:47Z","timestamp":1664884847000},"source":"Crossref","is-referenced-by-count":16,"title":["NLRC4-mediated activation of CD1c+ DC contributes to perpetuation of synovitis in rheumatoid arthritis"],"prefix":"10.1172","volume":"7","author":[{"given":"Cristina","family":"Delgado-Ar\u00e9valo","sequence":"first","affiliation":[{"name":"Immunology Unit from Hospital Universitario La Princesa, Medicine Faculty, Autonomous University of Madrid (UAM), Instituto Investigaci\u00f3n Sanitaria-Princesa IIS-IP, Madrid, 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Unit from Hospital Universitario La Princesa, Medicine Faculty, Autonomous University of Madrid (UAM), Instituto Investigaci\u00f3n Sanitaria-Princesa IIS-IP, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9314-0998","authenticated-orcid":true,"given":"Roberto","family":"Moreno-Vellisca","sequence":"additional","affiliation":[{"name":"Genomic Unit, The National Centre for Cardiovascular Research, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortensia","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"Immunology Unit from Hospital Universitario La Princesa, Medicine Faculty, Autonomous University of Madrid (UAM), Instituto Investigaci\u00f3n Sanitaria-Princesa IIS-IP, Madrid, Spain."},{"name":"CIBER Cardiovascular, Madrid, 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