{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:31:17Z","timestamp":1793723477972,"version":"4.6.1"},"reference-count":37,"publisher":"American Society for Clinical Investigation","issue":"17","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"crossref","award":["FDT20170739031"],"award-info":[{"award-number":["FDT20170739031"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Association Fran\u00e7aise contre les Myopathies","award":["22281"],"award-info":[{"award-number":["22281"]}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"crossref","award":["ANR-10-LABX-0046"],"award-info":[{"award-number":["ANR-10-LABX-0046"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"crossref","award":["694717"],"award-info":[{"award-number":["694717"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,8]]},"abstract":"<jats:p>\n                    The sarcoplasmic reticulum (SR) plays an important role in calcium homeostasis. SR calcium mishandling is described in pathological conditions, such as myopathies. Here, we investigated whether the nuclear receptor subfamily 1 group D member (NR1D1, also called REV-ERB\u03b1) regulates skeletal muscle SR calcium homeostasis. Our data demonstrate that NR1D1 deficiency in mice impaired sarco\/endoplasmic reticulum calcium ATPase\u2013dependent (SERCA-dependent) SR calcium uptake. NR1D1 acts on calcium homeostasis by repressing the SERCA inhibitor myoregulin through direct binding to its promoter. Restoration of myoregulin counteracted the effects of NR1D1 overexpression on SR calcium content. Interestingly, myoblasts from patients with Duchenne muscular dystrophy displayed lower NR1D1 expression, whereas pharmacological NR1D1 activation ameliorated SR calcium homeostasis and improved muscle structure and function in dystrophic\n                    <jats:italic>\n                      mdx\/Utr\n                      <jats:sup>+\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Our findings demonstrate that NR1D1 regulates muscle SR calcium homeostasis, pointing to its therapeutic potential for mitigating myopathy.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.153584","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T12:02:55Z","timestamp":1659441775000},"source":"Crossref","is-referenced-by-count":22,"title":["NR1D1 controls skeletal muscle calcium homeostasis through myoregulin repression"],"prefix":"10.1172","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6886-6140","authenticated-orcid":true,"given":"Alexis","family":"Boulinguiez","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Duhem","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Mayeuf-Louchart","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Pourcet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1813-810X","authenticated-orcid":true,"given":"Yasmine","family":"Sebti","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kateryna","family":"Kondratska","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, Inserm, U1003 \u2014 PHYCEL \u2014 Physiologie Cellulaire, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7286-4209","authenticated-orcid":true,"given":"Val\u00e9rie","family":"Montel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, Universit\u00e9 d\u2019Artois, Universit\u00e9 du Littoral C\u00f4te d\u2019Opale, EA 7369 \u2014 URePSSS \u2014 Unit\u00e9 de Recherche Pluridisciplinaire Sport Sant\u00e9 Soci\u00e9t\u00e9, Lille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9438-6730","authenticated-orcid":true,"given":"St\u00e9phane","family":"Delhaye","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, 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