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Inhibition of the noncanonical I\u03baB kinases TANK-binding kinase 1 and IKK\u03b5 with amlexanox restores insulin sensitivity and glucose homeostasis in diabetic mice and human patients. Here we report that amlexanox improves diet-induced hypertriglyceridemia and hypercholesterolemia in Western diet\u2013fed (WD-fed)\n                    <jats:italic>Ldlr<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice and protects against atherogenesis. Amlexanox ameliorated dyslipidemia, inflammation, and vascular dysfunction through synergistic actions that involve upregulation of bile acid synthesis to increase cholesterol excretion. Transcriptomic profiling demonstrated an elevated expression of key bile acid synthesis genes. Furthermore, we found that amlexanox attenuated monocytosis, eosinophilia, and vascular dysfunction during WD-induced atherosclerosis. These findings demonstrate the potential of amlexanox as a therapy for hypercholesterolemia and atherosclerosis.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.155552","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T12:02:20Z","timestamp":1659441740000},"source":"Crossref","is-referenced-by-count":29,"title":["The TBK1\/IKK\u03b5 inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis"],"prefix":"10.1172","volume":"7","author":[{"given":"Peng","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Structural Biology and"},{"name":"Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA."},{"name":"Department of Medicine, University of California, San Diego (UCSD), La Jolla, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Sun","sequence":"additional","affiliation":[{"name":"Mays Cancer 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