{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:54:12Z","timestamp":1782370452100,"version":"3.54.5"},"reference-count":77,"publisher":"American Society for Clinical Investigation","issue":"16","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM072808"],"award-info":[{"award-number":["GM072808"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM095442"],"award-info":[{"award-number":["GM095442"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM104323"],"award-info":[{"award-number":["GM104323"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AA027396"],"award-info":[{"award-number":["AA027396"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI149274"],"award-info":[{"award-number":["AI149274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK72564"],"award-info":[{"award-number":["DK72564"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK61379"],"award-info":[{"award-number":["DK61379"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,22]]},"abstract":"<jats:p>\n                    Expression of the tight junction\u2013associated protein junctional adhesion molecule-A (JAM-A) is increased in sepsis, although the significance of this is unknown. Here, we show that septic JAM-A\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice have increased gut permeability, yet paradoxically have decreased bacteremia and systemic TNF and IL-1\u03b2 expression. Survival is improved in JAM-A\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice. However, intestine-specific JAM-A\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    deletion does not alter mortality, suggesting that the mortality benefit conferred in mice lacking JAM-A is independent of the intestine. Septic JAM-A\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice have increased numbers of splenic CD44\n                    <jats:sup>hi<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, decreased frequency of TNF\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    cells, and elevated frequency of IL-2\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    cells. Septic JAM-A\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice have increased numbers of B cells in mesenteric lymph nodes with elevated serum IgA and intraepithelial lymphocyte IgA production. JAM-A\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    \u00d7 RAG\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice have improved survival compared with RAG\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice and identical mortality as WT mice. Gut neutrophil infiltration and neutrophil phagocytosis are increased in JAM-A\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice, while septic JAM-A\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice depleted of neutrophils lose their survival advantage. Therefore, increased bacterial clearance via neutrophils and an altered systemic inflammatory response with increased opsonizing IgA produced through the adaptive immune system results in improved survival in septic JAM-A\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice. JAM-A may be a therapeutic target in sepsis via immune mechanisms not related to its role in permeability.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.156255","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T12:00:49Z","timestamp":1657627249000},"source":"Crossref","is-referenced-by-count":22,"title":["Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis"],"prefix":"10.1172","volume":"7","author":[{"given":"Nathan J.","family":"Klingensmith","sequence":"first","affiliation":[{"name":"Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine T.","family":"Fay","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Swift","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9847-4623","authenticated-orcid":true,"given":"Julia M.R.","family":"Bazzano","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4937-2019","authenticated-orcid":true,"given":"Ching-wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia, USA."},{"name":"Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly M.","family":"Ramonell","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7055-942X","authenticated-orcid":true,"given":"Eileen M.","family":"Burd","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Parkos","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6736-4421","authenticated-orcid":true,"given":"Mandy L.","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Transplant Center, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig M.","family":"Coopersmith","sequence":"additional","affiliation":[{"name":"Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.13836"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004224"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002255"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000800"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-019-0372-6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2015.11.004"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.03.005"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.013"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.169"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/cpim.112"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000565"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03327-1"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/path.2525"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000709"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802188R"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002172"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02989-1"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa682"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2020.04.001"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.193482"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0143-7"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2729-0"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2020.183299"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04034.x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071416"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.017"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e13-06-0298"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E18-08-0531"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2017"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(99)00122-4"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0421-0"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01661"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001463"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.99722"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1986.01400020082010"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nri2653"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001759"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2016.00256"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1097\/00075198-200304000-00011"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060219"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001088"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.06.011"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.602094"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/nri2274"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317477"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-0063-3"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202656"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050795"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.025"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804008"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1239"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404689"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02532"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00992-w"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/nature22058"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1177\/0885066620965169"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-018-0466-7"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.01.005"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2016.05.062"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500147102"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-047431"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.037127"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10054"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803039"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23753"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.13.1716"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.14670\/HH-22.623"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-199704000-00002"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001670"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003685"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000534"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21231"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.06.022"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001212"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.303"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/156255\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:30:14Z","timestamp":1779147014000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/156255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,22]]},"references-count":77,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8,22]]},"published-print":{"date-parts":[[2022,8,22]]}},"alternative-id":["10.1172\/jci.insight.156255"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.156255","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,22]]},"article-number":"e156255"}}