{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:45:39Z","timestamp":1792115139589,"version":"4.4.0"},"reference-count":45,"publisher":"American Society for Clinical Investigation","issue":"21","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["21H02764"],"award-info":[{"award-number":["21H02764"]}]},{"name":"JSPS KAKENHI","award":["20H03755"],"award-info":[{"award-number":["20H03755"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,8]]},"abstract":"<jats:p>\n                    Accumulating evidence suggests that high levels of\n                    <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    in colorectal tumor tissues can be associated with poor prognosis in patients with colorectal cancer (CRC); however, data regarding distinct prognostic subgroups in\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    \u2013positive CRC remain limited. Herein, we demonstrate that high-iron status was associated with a worse prognosis in patients with CRC with\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    . Patients with CRC presenting elevated serum transferrin saturation exhibited preferential iron deposition in macrophages in the tumor microenvironment. In addition,\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    induced\n                    <jats:italic>CCL8<\/jats:italic>\n                    expression in macrophages via the TLR4\/NF-\u03baB signaling pathway, which was inhibited by iron deficiency. Mechanistically, iron attenuated the inhibitory phosphorylation of NF-\u03baB p65 by activating serine\/threonine phosphatases, augmenting tumor-promoting chemokine production in macrophages. Our observations indicate a key role for iron in modulating the NF-\u03baB signaling pathway and suggest its prognostic potential as a determining factor for interpatient heterogeneity in\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    \u2013positive CRC.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.156802","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T12:06:22Z","timestamp":1663848382000},"source":"Crossref","is-referenced-by-count":34,"title":["Iron accelerates Fusobacterium nucleatum\u2013induced CCL8 expression in macrophages and is associated with colorectal cancer progression"],"prefix":"10.1172","volume":"7","author":[{"given":"Taishi","family":"Yamane","sequence":"first","affiliation":[{"name":"Department of Cell Signaling and Metabolic Medicine, Faculty of Life Sciences,"},{"name":"Department of Gastroenterological Surgery, Graduate School of Medical 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