{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:45:07Z","timestamp":1793727907590,"version":"4.6.1"},"reference-count":56,"publisher":"American Society for Clinical Investigation","issue":"24","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH \/ NIDDK","award":["R01DK101730"],"award-info":[{"award-number":["R01DK101730"]}]},{"name":"NIH \/ NIDDK","award":["R01DK132342"],"award-info":[{"award-number":["R01DK132342"]}]},{"name":"NIH \/ NIDDK","award":["R01DK131046"],"award-info":[{"award-number":["R01DK131046"]}]},{"name":"NIH \/ NIDDK","award":["R01DK102815"],"award-info":[{"award-number":["R01DK102815"]}]},{"name":"NIH \/ NIDDK","award":["R01DK114158"],"award-info":[{"award-number":["R01DK114158"]}]},{"name":"VA","award":["1IK6BX004835"],"award-info":[{"award-number":["1IK6BX004835"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,22]]},"abstract":"<jats:p>\n                    Fibroblast growth factor 23 (FGF23) is a phosphate-regulating (Pi-regulating) hormone produced by bone. Hereditary hypophosphatemic disorders are associated with FGF23 excess, impaired skeletal growth, and osteomalacia. Blocking FGF23 became an effective therapeutic strategy in X-linked hypophosphatemia, but testing remains limited in autosomal recessive hypophosphatemic rickets (ARHR). This study investigates the effects of Pi repletion and bone-specific deletion of\n                    <jats:italic>Fgf23<\/jats:italic>\n                    on bone and mineral metabolism in the dentin matrix protein 1\u2013knockout (\n                    <jats:italic>Dmp1<\/jats:italic>\n                    <jats:sup>KO<\/jats:sup>\n                    ) mouse model of ARHR. At 12 weeks,\n                    <jats:italic>Dmp1<\/jats:italic>\n                    <jats:sup>KO<\/jats:sup>\n                    mice showed increased serum FGF23 and parathyroid hormone levels, hypophosphatemia, impaired growth, rickets, and osteomalacia. Six weeks of dietary Pi supplementation exacerbated FGF23 production, hyperparathyroidism, renal Pi excretion, and osteomalacia. In contrast, osteocyte-specific deletion of\n                    <jats:italic>Fgf23<\/jats:italic>\n                    resulted in a partial correction of FGF23 excess, which was sufficient to fully restore serum Pi levels but only partially corrected the bone phenotype. In vitro, we show that FGF23 directly impaired osteoprogenitors\u2019 differentiation and that DMP1 deficiency contributed to impaired mineralization independent of FGF23 or Pi levels. In conclusion, FGF23-induced hypophosphatemia is only partially responsible for the bone defects observed in\n                    <jats:italic>Dmp1<\/jats:italic>\n                    <jats:sup>KO<\/jats:sup>\n                    mice. Our data suggest that combined DMP1 repletion and FGF23 blockade could effectively correct ARHR-associated mineral and bone disorders.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.156850","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T12:00:17Z","timestamp":1699531217000},"source":"Crossref","is-referenced-by-count":18,"title":["FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice"],"prefix":"10.1172","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2410-4571","authenticated-orcid":true,"given":"Guillaume","family":"Courbon","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Center for Translational Metabolism and Health, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Kentrup","sequence":"additional","affiliation":[{"name":"Division of Nephrology 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