{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:43:06Z","timestamp":1793256186551,"version":"4.5.0"},"reference-count":33,"publisher":"American Society for Clinical Investigation","issue":"11","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["U19AI118610 NIAID"],"award-info":[{"award-number":["U19AI118610 NIAID"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Allergy and Infectious Diseases, National Institutes of Health","award":["HHSN272200900010C"],"award-info":[{"award-number":["HHSN272200900010C"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,8]]},"abstract":"<jats:p>Understanding the immune response to dengue virus (DENV) is essential for developing a dengue vaccine that is protective against all 4 DENV serotypes. We evaluated the immune response after vaccination (live attenuated tetravalent dengue vaccine TV005 or trivalent admixture) and after challenge with DEN2\u039430 (Tonga\/74) to better understand the importance of homotypic immunity in vaccine protection. Significant increases in IP-10 expression were observed following receipt of either the trivalent or tetravalent vaccine. After challenge, a large increase in IP-10 expression was observed in the placebo and trivalent admixture groups but not in the tetravalent vaccine group. MCP-1, IL-1RA, and MIP-1\u03b2 exhibited a similar pattern as IP-10. These results demonstrate protective effects of trivalent and tetravalent vaccines against DENV and suggest that the tetravalent vaccine has a better protective effect compared with the trivalent admixture. We also explored the postvaccination and postchallenge immune response differences between Black and White participants. White participants responded to vaccine differently than Black participants; Black participants receiving trivalent and tetravalent vaccines responded strongly and White participants responded only transiently in trivalent group. In response to challenge, White participants elicited a stronger response than Black participants. These results may explain why White participants may have a more vigorous DENV immune response than Black participants, as reported in literature.<\/jats:p>","DOI":"10.1172\/jci.insight.157811","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T12:01:07Z","timestamp":1651752067000},"source":"Crossref","is-referenced-by-count":16,"title":["The innate immune response following multivalent dengue vaccination and implications for protection against dengue challenge"],"prefix":"10.1172","volume":"7","author":[{"given":"Ruixue","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Population Health Science and Policy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4545-7138","authenticated-orcid":true,"given":"Lewis E.","family":"Tomalin","sequence":"additional","affiliation":[{"name":"Department of Population Health Science and Policy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Pintado","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-4400","authenticated-orcid":true,"given":"Seunghee","family":"Kim-Schulze","sequence":"additional","affiliation":[{"name":"Department of Oncological Science and Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S.","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3405-6702","authenticated-orcid":true,"given":"Ana","family":"Fernandez-Sesma","sequence":"additional","affiliation":[{"name":"Department of Microbiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6652-2851","authenticated-orcid":true,"given":"Anna P.","family":"Durbin","sequence":"additional","affiliation":[{"name":"Bloomberg School of Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA."},{"name":"School of Medicine, Johns Hopkins School of Public Health, Baltimore, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8712-3553","authenticated-orcid":true,"given":"Mayte","family":"Su\u00e1rez-Fari\u00f1as","sequence":"additional","affiliation":[{"name":"Department of Population Health Science and Policy,"},{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"issue":"36","key":"B1","first-page":"457","article-title":"Dengue vaccines: WHO position paper \u2014 September 2018","volume":"93","author":"World Health","year":"2018","journal-title":"Wkly Epidemiol Rec"},{"issue":"3","key":"B2","first-page":"178","article-title":"Dengue vaccine: global development update","volume":"10","author":"Prompetchara","year":"2019","journal-title":"Asian Pac J Allergy Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2016.1115727"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8010063"},{"issue":"330","key":"B5","doi-asserted-by":"crossref","first-page":"330ra36","DOI":"10.1126\/scitranslmed.aaf1517","article-title":"The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a human challenge model","volume":"8","author":"Kirkpatrick","year":"2016","journal-title":"Sci Transl Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001742"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.9.5516-5528.2005"},{"issue":"4","key":"B8","first-page":"375","article-title":"Dengue haemorrhagic fever\/dengue shock syndrome: lessons from the Cuban epidemic, 1981","volume":"67","author":"Kouri","year":"1989","journal-title":"Bull World Health Organ"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-006-0869-x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822011005000044"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.4"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2006.19.662"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506223"},{"issue":"3","key":"B14","first-page":"351","article-title":"Dissecting antibodies induced by a chimeric yellow fever-dengue, live-attenuated, tetravalent dengue vaccine (CYD-TDV) in naive and dengue-exposed individuals","volume":"215","author":"Henein","year":"2017","journal-title":"J Infect Dis"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.5.3185"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-8-86"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.06.001"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82093-0"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02637"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25561"},{"key":"B21","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2261-7-30","article-title":"Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study","volume":"7","author":"Tang","year":"2007","journal-title":"BMC Cardiovasc Disord"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2009.0045"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13389"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313282"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis936"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1596-x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s13337-015-0296-2"},{"issue":"8540","key":"B28","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0140-6736(87)92289-6","article-title":"Antibody-dependent enhancement of dengue 2 virus in people of white descent in Cuba","volume":"329","author":"Morier","year":"1987","journal-title":"Lancet"},{"issue":"2","key":"B29","first-page":"282","article-title":"Gamma interferon stimulates monocyte chemotactic protein (MCP-1) in human mesangial cells","volume":"123","author":"Grandaliano","year":"1994","journal-title":"J Lab Clin Med"},{"issue":"7","key":"B30","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.4049\/jimmunol.161.7.3719","article-title":"A complex element regulates IFN-gamma-stimulated monocyte chemoattractant protein-1 gene transcription","volume":"161","author":"Valente","year":"1998","journal-title":"J Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.4.1084"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004830"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004497"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/157811\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:34:24Z","timestamp":1779147264000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/157811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,8]]},"references-count":33,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,6,8]]},"published-print":{"date-parts":[[2022,6,8]]}},"alternative-id":["10.1172\/jci.insight.157811"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.157811","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,8]]},"article-number":"e157811"}}