{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T08:43:09Z","timestamp":1794040989453,"version":"4.8.0"},"reference-count":32,"publisher":"American Society for Clinical Investigation","issue":"10","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,23]]},"abstract":"<jats:p>\n                    The RTS,S\/AS01E vaccine targets the circumsporozoite protein (CSP) of the\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    ) parasite. Protein microarrays were used to measure levels of IgG against 1000\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    antigens in 2138 infants (age 6\u201312 weeks) and children (age 5\u201317 months) from 6 African sites of the phase III trial, sampled before and at 4 longitudinal visits after vaccination. One month postvaccination, IgG responses to 17% of all probed antigens showed differences between RTS,S\/AS01E and comparator vaccination groups, whereas no prevaccination differences were found. A small subset of antigens presented IgG levels reaching 4- to 8-fold increases in the RTS,S\/AS01E group, comparable in magnitude to anti-CSP IgG levels (~11-fold increase). They were strongly cross-correlated and correlated with anti-CSP levels, waning similarly over time and reincreasing with the booster dose. Such an intriguing phenomenon may be due to cross-reactivity of anti-CSP antibodies with these antigens. RTS,S\/AS01E vaccinees with strong off-target IgG responses had an estimated lower clinical malaria incidence after adjusting for age group, site, and postvaccination anti-CSP levels. RTS,S\/AS01E-induced IgG may bind strongly not only to CSP, but also to unrelated malaria antigens, and this seems to either confer, or at least be a marker of, increased protection from clinical malaria.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.158030","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T12:00:41Z","timestamp":1650542441000},"source":"Crossref","is-referenced-by-count":12,"title":["Strong off-target antibody reactivity to malarial antigens induced by RTS,S\/AS01E vaccination is associated with protection"],"prefix":"10.1172","volume":"7","author":[{"given":"D\u00eddac","family":"Maci\u00e0","sequence":"first","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Catalonia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-0917","authenticated-orcid":true,"given":"Joseph J.","family":"Campo","sequence":"additional","affiliation":[{"name":"Antigen Discovery, Inc (ADI), Irvine, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5105-9836","authenticated-orcid":true,"given":"Gemma","family":"Moncunill","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Catalonia, Spain."},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6060-8673","authenticated-orcid":true,"given":"Chenjerai","family":"Jairoce","sequence":"additional","affiliation":[{"name":"Manhi\u00e7a Health Research Center (CISM), Maputo, Mozambique."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto J.","family":"Nhabomba","sequence":"additional","affiliation":[{"name":"Manhi\u00e7a Health Research Center (CISM), Maputo, Mozambique."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Mpina","sequence":"additional","affiliation":[{"name":"Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania."},{"name":"Swiss Tropical and Public Health Institute, Basel, Switzerland."},{"name":"University of Basel, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1595-5152","authenticated-orcid":true,"given":"Hermann","family":"Sorgho","sequence":"additional","affiliation":[{"name":"Nanoro Clinical Research Unit, Health Science Research Institute, Nanoro, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5152-462X","authenticated-orcid":true,"given":"David","family":"Dosoo","sequence":"additional","affiliation":[{"name":"Kintampo Health Research Centre, Kintampo, Brong-Ahafo, Ghana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1873-6473","authenticated-orcid":true,"given":"Ousmane","family":"Traore","sequence":"additional","affiliation":[{"name":"Nanoro Clinical Research Unit, Health Science Research Institute, Nanoro, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwadwo Asamoah","family":"Kusi","sequence":"additional","affiliation":[{"name":"Department of Electron Microscopy & Histopathology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3520-7573","authenticated-orcid":true,"given":"Nana Aba","family":"Williams","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Catalonia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Oberai","sequence":"additional","affiliation":[{"name":"Antigen Discovery, Inc (ADI), Irvine, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlo","family":"Randall","sequence":"additional","affiliation":[{"name":"Antigen Discovery, Inc (ADI), Irvine, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e8ctor","family":"Sanz","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Catalonia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Valim","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T.H. Chen School of Public Health, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwaku Poku","family":"Asante","sequence":"additional","affiliation":[{"name":"Kintampo Health Research Centre, Kintampo, Brong-Ahafo, Ghana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Owusu-Agyei","sequence":"additional","affiliation":[{"name":"Kintampo Health Research Centre, Kintampo, Brong-Ahafo, Ghana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-3586","authenticated-orcid":true,"given":"Halidou","family":"Tinto","sequence":"additional","affiliation":[{"name":"Nanoro Clinical Research Unit, Health Science Research Institute, Nanoro, Burkina Faso."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selidji Todagbe","family":"Agnandji","sequence":"additional","affiliation":[{"name":"Lambar\u00e9n\u00e9 Medical Research Center (CERMEL), Lambar\u00e9n\u00e9, Gabon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-5550","authenticated-orcid":true,"given":"Simon","family":"Kariuki","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute\/Centre for Global Health, Kisumu, Siaya, Nairobi, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Gyan","sequence":"additional","affiliation":[{"name":"Kintampo Health Research Centre, Kintampo, Brong-Ahafo, Ghana."},{"name":"Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7136-0642","authenticated-orcid":true,"given":"Claudia","family":"Daubenberger","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Basel, Switzerland."},{"name":"University of Basel, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Mordm\u00fcller","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain."},{"name":"Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands."},{"name":"Institute of Tropical Medicine and German Center for Infection Research, University of T\u00fcbingen, T\u00fcbingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Petrone","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Catalonia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-4060","authenticated-orcid":true,"given":"Carlota","family":"Doba\u00f1o","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Catalonia, Spain."},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"B1","unstructured":"WHO. 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