{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:08:39Z","timestamp":1779149319610,"version":"3.51.4"},"reference-count":69,"publisher":"American Society for Clinical Investigation","issue":"12","funder":[{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"crossref","award":["ASH Bridge"],"award-info":[{"award-number":["ASH Bridge"]}],"id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The CLL Global Research Foundation","award":["540725"],"award-info":[{"award-number":["540725"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 CA238523"],"award-info":[{"award-number":["R01 CA238523"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 CA238523"],"award-info":[{"award-number":["R01 CA238523"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"crossref","award":["ASH Bridge"],"award-info":[{"award-number":["ASH Bridge"]}],"id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The CLL Global Research Foundation","award":["540725"],"award-info":[{"award-number":["540725"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,22]]},"abstract":"<jats:p>\n                    Chronic lymphocytic leukemia (CLL) results from expansion of a CD5\n                    <jats:sup>+<\/jats:sup>\n                    B cell clone that requires interactions with other cell types, including T cells. Moreover, patients with CLL have elevated levels of circulating IL-17A\n                    <jats:sup>+<\/jats:sup>\n                    and IL-17F\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T (Th17) cells, with higher numbers of IL-17A\n                    <jats:sup>+<\/jats:sup>\n                    Th17 cells correlating with better outcomes. We report that CLL Th17 cells expressed more miR155, a Th17-differentiation regulator, than control Th17 cells, despite naive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T (Tn) cell basal miR155 levels being similar in both. We also found that CLL cells directly regulated miR155 levels in Tn cells, thereby affecting Th17 differentiation, by documenting that coculturing Tn cells with resting or activated (B\n                    <jats:sub>act<\/jats:sub>\n                    ) CLL cells altered the magnitude and direction of T cell miR155 levels; CLL B\n                    <jats:sub>act<\/jats:sub>\n                    cells promoted IL-17A\n                    <jats:sup>+<\/jats:sup>\n                    and IL-17F\n                    <jats:sup>+<\/jats:sup>\n                    T cell generation by an miR155-dependent mechanism, confirmed by miR155 inhibition; coculture of Tn cells with CLL B\n                    <jats:sub>act<\/jats:sub>\n                    cells led to a linear correlation between the degree and direction of T cell miR155 expression changes and production of IL-17F but not IL-17A; and B\n                    <jats:sub>act<\/jats:sub>\n                    cell\u2013mediated changes in Tn cell miR155 expression correlated with outcome, irrespective of IGHV mutation status, a strong prognostic indicator. These results identify a potentially unrecognized CLL B\n                    <jats:sub>act<\/jats:sub>\n                    cell\u2013dependent mechanism, upregulation of Tn cell miR155 expression and subsequent enhancement of IL-17F\n                    <jats:sup>+<\/jats:sup>\n                    Th17 generation, that favors better clinical courses.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.158243","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T12:01:16Z","timestamp":1651752076000},"source":"Crossref","is-referenced-by-count":4,"title":["Activated CLL cells regulate IL-17F\u2013producing Th17 cells in miR155-dependent and outcome-specific manners"],"prefix":"10.1172","volume":"7","author":[{"given":"Byeongho","family":"Jung","sequence":"first","affiliation":[{"name":"Karches Center for Oncology Research, Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, 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