{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:44:49Z","timestamp":1793130289126,"version":"4.5.0"},"reference-count":51,"publisher":"American Society for Clinical Investigation","issue":"13","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH intramural research program, Military Infectious Disease Research Program, New York State","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,8]]},"abstract":"<jats:p>\n                    Vaccine-elicited SARS-CoV-2 antibody responses are an established correlate of protection against viral infection in humans and nonhuman primates. However, it is less clear that vaccine-induced immunity is able to limit infection-elicited inflammation in the lower respiratory tract. To assess this, we collected bronchoalveolar lavage fluid samples after SARS-CoV-2 strain USA-WA1\/2020 challenge from rhesus macaques vaccinated with mRNA-1273 in a dose-reduction study. Single-cell transcriptomic profiling revealed a broad cellular landscape 48 hours after challenge, with distinct inflammatory signatures that correlated with viral RNA burden in the lower respiratory tract. These inflammatory signatures included phagocyte-restricted expression of chemokines, such as\n                    <jats:italic>CXCL10<\/jats:italic>\n                    and\n                    <jats:italic>CCL3<\/jats:italic>\n                    , and the broad expression of IFN-induced genes, such as\n                    <jats:italic>MX1<\/jats:italic>\n                    ,\n                    <jats:italic>ISG15<\/jats:italic>\n                    , and\n                    <jats:italic>IFIT1<\/jats:italic>\n                    . Induction of these inflammatory profiles was suppressed by prior mRNA-1273 vaccination in a dose-dependent manner and negatively correlated with prechallenge serum and lung antibody titers against SARS-CoV-2 spike. These observations were replicated and validated in a second independent macaque challenge study using the B.1.351\/Beta variant of SARS-CoV-2. These data support a model wherein vaccine-elicited antibody responses restrict viral replication following SARS-CoV-2 exposure, including limiting viral dissemination to the lower respiratory tract and infection-mediated inflammation and pathogenesis.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.160039","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T12:01:01Z","timestamp":1654171261000},"source":"Crossref","is-referenced-by-count":9,"title":["mRNA-1273 vaccination protects against SARS-CoV-2\u2013elicited lung inflammation in nonhuman primates"],"prefix":"10.1172","volume":"7","author":[{"given":"Adam T.","family":"Waickman","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology and"},{"name":"Institute for Global Health and Translational Sciences, State University of New York Upstate Medical University, Syracuse, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Victor","sequence":"additional","affiliation":[{"name":"Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2152-2073","authenticated-orcid":true,"given":"Krista","family":"Newell","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Friberg","sequence":"additional","affiliation":[{"name":"Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn E.","family":"Foulds","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Roederer","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1897-499X","authenticated-orcid":true,"given":"Diane L.","family":"Bolton","sequence":"additional","affiliation":[{"name":"US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA."},{"name":"Henry M. 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