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Here, we show that SARA suppressed myofibroblast precursor transdifferentiation in a mouse model of scleroderma. Mice overexpressing\n                    <jats:italic>SARA<\/jats:italic>\n                    specifically in PDGFR-\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    pericytes and pan-leukocytes (\n                    <jats:italic>SARATg<\/jats:italic>\n                    ) developed significantly less skin fibrosis in response to bleomycin injection compared with wild-type littermates (\n                    <jats:italic>SARAWT<\/jats:italic>\n                    ). Single-cell RNA-Seq analysis of skin PDGFR-\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    cells implicated pericyte subsets assuming myofibroblast characteristics under fibrotic stimuli, and\n                    <jats:italic>SARA<\/jats:italic>\n                    overexpression blocked the transition. In addition, a cluster that expresses molecules associated with Th2 cells and macrophage activation was enriched in\n                    <jats:italic>SARAWT<\/jats:italic>\n                    mice, but not in\n                    <jats:italic>SARATg<\/jats:italic>\n                    mice, after bleomycin treatment. Th2-specific\n                    <jats:italic>Il-31<\/jats:italic>\n                    expression was increased in skin of the bleomycin-treated\n                    <jats:italic>SARAWT<\/jats:italic>\n                    mice and patients with scleroderma (or systemic sclerosis, SSc). Receptor-ligand analyses indicated that lymphocytes mediated pericyte transdifferentiation in\n                    <jats:italic>SARAWT<\/jats:italic>\n                    mice, while with\n                    <jats:italic>SARA<\/jats:italic>\n                    overexpression the myofibroblast activity of pericytes was suppressed. Together, these data suggest a potentially novel crosstalk between myofibroblast precursors and immune cells in the pathogenesis of SSc, in which SARA plays a critical role.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.160977","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T12:05:25Z","timestamp":1663848325000},"source":"Crossref","is-referenced-by-count":10,"title":["SARA suppresses myofibroblast precursor transdifferentiation in fibrogenesis in a mouse model of scleroderma"],"prefix":"10.1172","volume":"7","author":[{"given":"Katia","family":"Corano Scheri","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA."},{"name":"Pediatric Nephrology, Ann and Robert H. 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