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We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti\u2013RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2\u2013specific T cell response. The dramatic decrease in thymic function in people &gt; 60 years, which fueled alteration in T cell homeostasis, and their lower CD161\n                    <jats:sup>+<\/jats:sup>\n                    T cell levels were associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC homing, activation, and TLR-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the &gt; 60-year-old group, which was also related to lower specific T cell response after vaccination. These findings might be relevant for the improvement of the current vaccination strategies and for the development of new vaccine prototypes.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.161045","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T12:01:41Z","timestamp":1660046501000},"source":"Crossref","is-referenced-by-count":19,"title":["Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people"],"prefix":"10.1172","volume":"7","author":[{"given":"Joana","family":"Vitall\u00e9","sequence":"first","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital, Spanish Research Council (CSIC), 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