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We studied intestine-specific\n                    <jats:italic>Rbm47<\/jats:italic>\n                    -knockout mice (\n                    <jats:italic>Rbm47-IKO<\/jats:italic>\n                    ) following intestinal injury and made crosses into\n                    <jats:italic>\n                      Apc\n                      <jats:sup>Min\/+<\/jats:sup>\n                    <\/jats:italic>\n                    mice to examine alterations in intestinal proliferation, response to injury, and tumorigenesis. We also interrogated human colorectal polyps and colon carcinoma tissue.\n                    <jats:italic>Rbm47-IKO<\/jats:italic>\n                    mice exhibited increased proliferation and abnormal villus morphology and cellularity, with corresponding changes in\n                    <jats:italic>Rbm47-IKO<\/jats:italic>\n                    organoids.\n                    <jats:italic>Rbm47-IKO<\/jats:italic>\n                    mice adapted to radiation injury and were protected against chemical-induced colitis, with\n                    <jats:italic>Rbm47-IKO<\/jats:italic>\n                    intestine showing upregulation of antioxidant and Wnt signaling pathways as well as stem cell and developmental genes. Furthermore,\n                    <jats:italic>Rbm47-IKO<\/jats:italic>\n                    mice were protected against colitis-associated cancer. By contrast, aged\n                    <jats:italic>Rbm47-IKO<\/jats:italic>\n                    mice developed spontaneous polyposis, and\n                    <jats:italic>Rbm47-IKO<\/jats:italic>\n                    <jats:italic>\n                      Apc\n                      <jats:sup>Min\/+<\/jats:sup>\n                    <\/jats:italic>\n                    mice manifested an increased intestinal polyp burden.\n                    <jats:italic>RBM47<\/jats:italic>\n                    mRNA was decreased in human colorectal cancer versus paired normal tissue, along with alternative splicing of tight junction protein 1 mRNA. Public databases revealed stage-specific reduction in RBM47 expression in colorectal cancer associated independently with decreased overall survival. These findings implicate RBM47 as a cell-intrinsic modifier of intestinal growth, inflammatory, and tumorigenic pathways.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.161118","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T23:18:47Z","timestamp":1680650327000},"source":"Crossref","is-referenced-by-count":23,"title":["RBM47 regulates intestinal injury and tumorigenesis by modifying proliferation, oxidative response, and inflammatory pathways"],"prefix":"10.1172","volume":"8","author":[{"given":"Saeed","family":"Soleymanjahi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Blanc","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth 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