{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:01Z","timestamp":1792787641859,"version":"4.5.0"},"reference-count":75,"publisher":"American Society for Clinical Investigation","issue":"3","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["310030_204167\/1"],"award-info":[{"award-number":["310030_204167\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Cystic Fibrosis Switzerland","award":["110422"],"award-info":[{"award-number":["110422"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:p>\n                    Cystic fibrosis (CF) is characterized by chronic bacterial infections leading to progressive bronchiectasis and respiratory failure.\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    (\n                    <jats:italic>Pa<\/jats:italic>\n                    ) is the predominant opportunistic pathogen infecting the CF airways. The guanine nucleotide exchange factor Vav3 plays a critical role in\n                    <jats:italic>Pa<\/jats:italic>\n                    adhesion to the CF airways by inducing luminal fibronectin deposition that favors bacteria trapping. Here we report that Vav3 overexpression in CF is caused by upregulation of the mRNA-stabilizing protein HuR. We found that HuR accumulates in the cytoplasm of CF airway epithelial cells and that it binds to and stabilizes Vav3 mRNA. Interestingly, disruption of the HuR-Vav3 mRNA interaction improved the CF epithelial integrity, inhibited the formation of the fibronectin-made bacterial docking platforms, and prevented\n                    <jats:italic>Pa<\/jats:italic>\n                    adhesion to the CF airway epithelium. These findings indicate that targeting HuR represents a promising antiadhesive approach in CF that can prevent initial stages of\n                    <jats:italic>Pa<\/jats:italic>\n                    infection in a context of emergence of multidrug-resistant pathogens.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.161961","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T12:00:54Z","timestamp":1672920054000},"source":"Crossref","is-referenced-by-count":12,"title":["Targeting HuR-Vav3 mRNA interaction prevents Pseudomonas aeruginosa adhesion to the cystic fibrosis airway epithelium"],"prefix":"10.1172","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-9304","authenticated-orcid":true,"given":"Mehdi","family":"Badaoui","sequence":"first","affiliation":[{"name":"Department of Cell Physiology & Metabolism 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