{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:59:10Z","timestamp":1787018350418,"version":"build-2736575974"},"reference-count":77,"publisher":"American Society for Clinical Investigation","issue":"24","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,22]]},"abstract":"<jats:p>\n                    Leukocyte adhesion deficiency type 1 (LAD-1) is a rare disease resulting from mutations in the gene encoding for the common \u03b2-chain of the \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    -integrin family (CD18). The most prominent clinical symptoms are profound leukocytosis and high susceptibility to infections. Patients with LAD-1 are prone to develop autoimmune diseases, but the molecular and cellular mechanisms that result in coexisting immunodeficiency and autoimmunity are still unresolved. CD4\n                    <jats:sup>+<\/jats:sup>\n                    FOXP3\n                    <jats:sup>+<\/jats:sup>\n                    Treg are known for their essential role in preventing autoimmunity. To understand the role of Treg in LAD-1 development and manifestation of autoimmunity, we generated mice specifically lacking CD18 on Treg (CD18\n                    <jats:sup>Foxp3<\/jats:sup>\n                    ), resulting in defective LFA-1 expression. Here, we demonstrate a crucial role of LFA-1 on Treg to maintain immune homeostasis by modifying T cell\u2013DC interactions and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell activation. Treg-specific CD18 deletion did not impair Treg migration into extralymphatic organs, but it resulted in shorter interactions of Treg with DC. In vivo, CD18\n                    <jats:sup>Foxp3<\/jats:sup>\n                    mice developed spontaneous hyperplasia in lymphatic organs and diffuse inflammation of the skin and in multiple internal organs. Thus, LFA-1 on Treg is required for the maintenance of immune homeostasis.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.162580","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T12:01:36Z","timestamp":1667908896000},"source":"Crossref","is-referenced-by-count":11,"title":["Impaired Treg-DC interactions contribute to autoimmunity in leukocyte adhesion deficiency type 1"],"prefix":"10.1172","volume":"7","author":[{"given":"Tanja","family":"Klaus","sequence":"first","affiliation":[{"name":"Department of Dermatology,"},{"name":"Research Center for Immunotherapy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia S.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Research Center for Immunotherapy, and"},{"name":"Institute of Immunology, University of Mainz Medical Center, Mainz, 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