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Over one-third of vaccinated patients at the pre-booster time point were seronegative, and these patients were predominantly on active cancer therapies such as anti-CD20 monoclonal antibody. While booster immunization was able to induce detectable antibodies in a small fraction of seronegative patients, the overall booster benefit was disproportionately evident in patients already seropositive and not receiving active therapy. While ancestral virus\u2013 and Omicron variant\u2013reactive antibody levels among individual patients were largely concordant, neutralizing antibodies against Omicron tended to be reduced. Interestingly, in all patients, including those unable to generate detectable antibodies against SARS-CoV-2 spike, we observed comparable levels of EBV- and influenza-reactive antibodies, demonstrating that B cell\u2013targeting therapies primarily impair de novo but not preexisting antibody levels. These findings support rationale for vaccination before cancer treatment.<\/jats:p>","DOI":"10.1172\/jci.insight.163434","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T12:04:42Z","timestamp":1675771482000},"source":"Crossref","is-referenced-by-count":3,"title":["Selective suppression of de novo SARS-CoV-2 vaccine antibody responses in patients with cancer on B cell\u2013targeted therapy"],"prefix":"10.1172","volume":"8","author":[{"given":"Joseph H.","family":"Azar","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine;"},{"name":"The Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center \u2013 James;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8644-5825","authenticated-orcid":true,"given":"John P.","family":"Evans","sequence":"additional","affiliation":[{"name":"Center for Retrovirus 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