{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:25:02Z","timestamp":1793381102043,"version":"4.5.0"},"reference-count":44,"publisher":"American Society for Clinical Investigation","issue":"3","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sanofi","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:p>\n                    Ocular surface diseases, including conjunctivitis, are recognized as common comorbidities in atopic dermatitis (AD) and occur at an increased frequency in patients with AD treated with biologics targeting IL-4 receptor \u03b1 (IL-4R\u03b1) or IL-13. However, the inflammatory mechanisms underlying this pathology are unknown. Here, we developed a potentially novel mouse model of skin inflammation\u2013evoked conjunctivitis and showed that it is dependent on CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and basophils. Blockade of IL-4R\u03b1 partially attenuated conjunctivitis development, downregulated basophil activation, and led to a reduction in expression of genes related to type 2 cytokine responses. Together, these data suggest that an IL-4R\u03b1\/basophil axis plays a role in the development of murine allergic conjunctivitis. Interestingly, we found a significant augmentation of a number of genes that encode tear proteins and enzymes in anti\u2013IL-4R\u03b1\u2013treated mice, and it may underlie the partial efficacy in this model and may represent candidate mediators of the increased frequency of conjunctivitis following dupilumab in patients with AD.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.163495","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T12:00:32Z","timestamp":1673352032000},"source":"Crossref","is-referenced-by-count":11,"title":["Cellular mechanisms and effects of IL-4 receptor blockade in experimental conjunctivitis evoked by skin inflammation"],"prefix":"10.1172","volume":"8","author":[{"given":"Hongwei","family":"Han","sequence":"first","affiliation":[{"name":"Sanofi, Immunology and Inflammation Research Therapeutic Area, Cambridge, Massachusetts, 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Observational Study of Conjunctivitis in the Setting of DUPIXENT\u00ae Treatment for Atopic Dermatitis. https:\/\/ClinicalTrials.gov\/show\/NCT04287608 Updated July 11, 2022. Accessed January 6, 2023"},{"issue":"3","key":"B41","first-page":"370","article-title":"Effects of vernal and allergic conjunctivitis on severity of keratoconus","volume":"6","author":"Cingu","year":"2013","journal-title":"Int J Ophthalmol"},{"key":"B42","unstructured":"ClinicalTrials. Evaluation of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC). https:\/\/ClinicalTrials.gov\/show\/NCT04296864 Updated November 26, 2021. 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