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Here, we created an experimental rest model in mice that briefly extends the morning rest period. We found in 2 major cardiovascular disease conditions (cardiac hypertrophy, myocardial infarction) that imposing a short, extended period of morning rest each day limited cardiac remodeling compared with controls. Mechanistically, rest mitigates autonomic-mediated hemodynamic stress on the cardiovascular system, relaxes myofilament contractility, and attenuates cardiac remodeling genes, consistent with the benefits on cardiac structure and function. These same rest-responsive gene pathways underlie the pathophysiology of many major human cardiovascular conditions, as demonstrated by interrogating open-source transcriptomic data; thus, patients with other conditions may also benefit from a morning rest period in a similar manner. Our findings implicate rest as a key driver of physiology, creating a potentially new field \u2014 as broad and important as diet, sleep, or exercise \u2014 and provide a strong rationale for investigation of rest-based therapy for major clinical diseases.<\/jats:p>","DOI":"10.1172\/jci.insight.164700","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T12:00:33Z","timestamp":1666094433000},"source":"Crossref","is-referenced-by-count":7,"title":["A brief morning rest period benefits cardiac repair in pressure overload hypertrophy and postmyocardial infarction"],"prefix":"10.1172","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1748-0501","authenticated-orcid":true,"given":"Cristine J.","family":"Reitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Rasouli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal J.","family":"Alibhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarak N.","family":"Khatua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0980-4729","authenticated-orcid":true,"given":"W. 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