{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:15:06Z","timestamp":1779142506430,"version":"3.51.4"},"reference-count":33,"publisher":"American Society for Clinical Investigation","issue":"22","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,22]]},"abstract":"<jats:p>\n                    In youths with obesity, the gut hormone potentiation of insulin secretion \u2014 the incretin effect \u2014 is blunted. We explored the longitudinal impact of the incretin effect during pubertal transition on \u03b2 cell function and insulin sensitivity. Youths with obesity and 2-hour glucose level \u2265 120 mg\/dL underwent a 3-hour oral glucose-tolerance test (OGTT) and an isoglycemic i.v. glucose infusion to quantify the incretin effect. After 2 years, 30 of 39 participants had a repeated OGTT and were stratified into 3 tertiles according to the baseline incretin effect. The high\u2013incretin effect group demonstrated a longitudinal increase in \u03b2 cell function (disposition index, minimal model [DI\n                    <jats:sub>MM<\/jats:sub>\n                    ]), with greater insulin sensitivity at follow-up and stable insulin secretion (\u03c6\n                    <jats:sub>total<\/jats:sub>\n                    ). A lower incretin effect at baseline was associated with higher 1-hour and 2-hour glucose level at follow-up. The high\u2013incretin effect group displayed a greater increase of GLP-1\n                    <jats:sub>7\u201336<\/jats:sub>\n                    than the moderate- and low-incretin group at baseline, while such a difference did not persist after 2 years. Glucagon suppression was reduced at follow-up in those with low-baseline incretin in respect to the high-incretin group. The incretin effect during pubertal transition affected the longitudinal trajectory of \u03b2 cell function and weight in youths with obesity.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.165709","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T12:00:24Z","timestamp":1697544024000},"source":"Crossref","is-referenced-by-count":5,"title":["Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity"],"prefix":"10.1172","volume":"8","author":[{"given":"Alfonso","family":"Galderisi","sequence":"first","affiliation":[{"name":"Yale University, Department of Pediatrics, New Haven, Connecticut, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7633-1346","authenticated-orcid":true,"given":"Domenico","family":"Tric\u00f2","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 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