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We assessed the antibody isotype\/subclass and Fc-receptor binding Luminex arrays of non\u2013SARS-CoV-2 and SARS-CoV-2 humoral responses among antiretroviral therapy\u2013treated (ART-treated) PWH. Among the entire cohort, COVID-19 infection was associated with higher cytomegalovirus (CMV) responses (vs. the COVID\n                    <jats:sup>\u2013<\/jats:sup>\n                    cohort ), potentially signifying increased susceptibility or a consequence of persistent inflammation. Among the COVID\n                    <jats:sup>+<\/jats:sup>\n                    participants, (a) higher BMI was associated with a striking amplification of SARS-CoV-2 responses, suggesting exaggerated inflammatory responses, and (b) lower nadir CD4 was associated with higher SARS-CoV-2 IgM and Fc\u03b3RIIB binding capacity, indicating poorly functioning extrafollicular and inhibitory responses. Among the COVID-19\n                    <jats:sup>\u2013<\/jats:sup>\n                    participants, female sex, older age, and lower nadir CD4 were associated with unique repertoire shifts. In this first comprehensive assessment of the humoral repertoire in a global cohort of PWH, we identify distinct SARS-CoV-2\u2013specific humoral immune profiles among PWH with obesity or lower nadir CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell count, underlining plausible mechanisms associated with worse COVID-19\u2013related outcomes in this setting. Host factors associated with the humoral repertoire in the COVID-19\n                    <jats:sup>\u2013<\/jats:sup>\n                    cohort enhance our understanding of these important shifts among PWH.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.166848","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T17:00:34Z","timestamp":1676912434000},"source":"Crossref","is-referenced-by-count":3,"title":["Effect of host factors and COVID-19 infection on the humoral immune repertoire in treated HIV"],"prefix":"10.1172","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9692-4405","authenticated-orcid":true,"given":"Samuel R.","family":"Schnittman","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, and"},{"name":"Metabolism Unit, Massachusetts General Hospital, Boston, Massachusetts, 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