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Several subsets of B cells possess the immunoregulatory capacity that limits tissue damage, yet the role of B cells in MIRI remains elusive. Here, we sought to elucidate the contribution of B cells to MIRI by transient ligation of the left anterior descending coronary artery in B cell\u2013depleted or \u2013deficient mice. Following ischemia and reperfusion (I\/R), regulatory B cells are rapidly recruited to the heart. B cell\u2013depleted or \u2013deficient mice exhibited exacerbated tissue damage, adverse cardiac remodeling, and an augmented inflammatory response after I\/R. Rescue and chimeric experiments indicated that the cardioprotective effect of B cells was not solely dependent on IL-10. Coculture experiments demonstrated that B cells induced neutrophil apoptosis through contact-dependent interactions, subsequently promoting reparative macrophage polarization by facilitating the phagocytosis of neutrophils by macrophages. The in vivo cardioprotective effect of B cells was undetectable in the absence of neutrophils after I\/R. Mechanistically, ligand-receptor imputation identified FCER2A as a potential mediator of interactions between B cells and neutrophils. Blocking FCER2A on B cells resulted in a reduction in the percentage of apoptotic neutrophils, contributing to the deterioration of cardiac remodeling. Our findings unveil a potential cardioprotective role of B cells in MIRI through mechanisms involving FCER2A, neutrophils, and macrophages.<\/jats:p>","DOI":"10.1172\/jci.insight.167201","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T09:16:51Z","timestamp":1707124611000},"source":"Crossref","is-referenced-by-count":28,"title":["B cell subsets contribute to myocardial protection by inducing neutrophil apoptosis after ischemia and reperfusion"],"prefix":"10.1172","volume":"9","author":[{"given":"Fangyang","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiology,"},{"name":"State Key Laboratory of Biotherapy and Cancer Center,"},{"name":"Laboratory of Heart Valve Disease,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology,"},{"name":"Laboratory of Heart Valve 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