{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:57:43Z","timestamp":1789084663725,"version":"build-2803163510"},"reference-count":59,"publisher":"American Society for Clinical Investigation","issue":"7","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["20K22879"],"award-info":[{"award-number":["20K22879"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["21K07418"],"award-info":[{"award-number":["21K07418"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,10]]},"abstract":"<jats:p>Human T lymphotropic virus type 1\u2013assoicated (HTLV-1\u2013associated) myelopathy\/tropical spastic paraparesis (HAM\/TSP) is a neuroinflammatory disease caused by the persistent proliferation of HTLV-1\u2013infected T cells. Here, we performed a T cell receptor (TCR) repertoire analysis focused on HTLV-1\u2013infected cells to identify and track the infected T cell clones that are preserved in patients with HAM\/TSP and migrate to the CNS. TCR\u03b2 repertoire analysis revealed higher clonal expansion in HTLV-1\u2013infected cells compared with noninfected cells from patients with HAM\/TSP and asymptomatic carriers (ACs). TCR clonality in HTLV-1\u2013infected cells was similar in patients with HAM\/TSP and ACs. Longitudinal analysis showed that the TCR repertoire signature in HTLV-1\u2013infected cells remained stable, and highly expanded infected clones were preserved within each patient with HAM\/TSP over years. Expanded HTLV-1\u2013infected clones revealed different distributions between cerebrospinal fluid (CSF) and peripheral blood and were enriched in the CSF of patients with HAM\/TSP. Cluster analysis showed similarity in TCR\u03b2 sequences in HTLV-1\u2013infected cells, suggesting that they proliferate after common antigen stimulation. Our results indicate that exploring TCR repertoires of HTLV-1\u2013infected cells can elucidate individual clonal dynamics and identify potential pathogenic clones expanded in the CNS.<\/jats:p>","DOI":"10.1172\/jci.insight.167422","type":"journal-article","created":{"date-parts":[[2023,4,9]],"date-time":"2023-04-09T14:01:19Z","timestamp":1681048879000},"source":"Crossref","is-referenced-by-count":12,"title":["Identification and tracking of HTLV-1\u2013infected T cell clones in virus-associated neurologic disease"],"prefix":"10.1172","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4909-7769","authenticated-orcid":true,"given":"Satoshi","family":"Nozuma","sequence":"first","affiliation":[{"name":"Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 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