{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:17:29Z","timestamp":1779142649616,"version":"3.51.4"},"reference-count":22,"publisher":"American Society for Clinical Investigation","issue":"9","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000182","name":"US Army Medical Research and Materiel Command","doi-asserted-by":"crossref","award":["W81XWH-18-2-0040"],"award-info":[{"award-number":["W81XWH-18-2-0040"]}],"id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["Y1-AI-2642-12"],"award-info":[{"award-number":["Y1-AI-2642-12"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,8]]},"abstract":"<jats:p>\n                    The RV144 phase III vaccine trial demonstrated that ALVAC-HIV and AIDSVAX B\/E administration over 6 months resulted in 31% efficacy in preventing HIV acquisition, while administration of AIDSVAX B\/E alone in both VAX003 and VAX004 studies failed to show efficacy. In this study, we aimed to understand the impact of ALVAC-HIV on the development of cellular, humoral, and functional immune responses compared to the administration of AIDSVAX B\/E alone. ALVAC-HIV in combination with 3 doses of AIDSVAX B\/E significantly increased CD4\n                    <jats:sup>+<\/jats:sup>\n                    HIV-specific T cell responses, polyfunctionality, and proliferation compared with 3 doses of AIDSVAX B\/E alone. Additionally, Env-specific plasmablasts and A244-specific memory B cells were identified with a significantly higher magnitude in the group that received ALVAC-HIV. Subsequently, data revealed increased magnitude of plasma IgG binding to and avidity for HIV Env in participants who received ALVAC-HIV compared with 3 doses of AIDSVAX B\/E alone. Lastly, levels of the Fc-mediated effector functions antibody-dependent cellular cytotoxicity, NK cell activation, and trogocytosis were significantly increased in participants who received ALVAC-HIV compared with those receiving AIDSVAX B\/E alone. Taken together, these results suggest that ALVAC-HIV plays an essential role in developing cellular and humoral immune responses to protein-boosted regimens relative to protein alone.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.167664","type":"journal-article","created":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T14:01:06Z","timestamp":1683468066000},"source":"Crossref","is-referenced-by-count":4,"title":["ALVAC-HIV and AIDSVAX B\/E vaccination induce improved immune responses compared with AIDSVAX B\/E vaccination alone"],"prefix":"10.1172","volume":"8","author":[{"given":"Margaret C.","family":"Costanzo","sequence":"first","affiliation":[{"name":"The US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA."},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1407-3414","authenticated-orcid":true,"given":"Dominic","family":"Paquin-Proulx","sequence":"additional","affiliation":[{"name":"The US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA."},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2829-1340","authenticated-orcid":true,"given":"Alexandra","family":"Schuetz","sequence":"additional","affiliation":[{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA."},{"name":"Armed Forces Research Institute for Medical Sciences, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6657-0960","authenticated-orcid":true,"given":"Siriwat","family":"Akapirat","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute for Medical Sciences, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanna","family":"Shubin","sequence":"additional","affiliation":[{"name":"The US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA."},{"name":"Henry M. 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