{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:11:41Z","timestamp":1790305901858,"version":"4.1.0"},"reference-count":50,"publisher":"American Society for Clinical Investigation","issue":"20","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"crossref","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013489","name":"Yakult Bio-Science Foundation","doi-asserted-by":"crossref","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100013489","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008667","name":"SENSHIN Medical Research Foundation","doi-asserted-by":"crossref","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100008667","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["19ek0109226h0003"],"award-info":[{"award-number":["19ek0109226h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["22K07996,22K08090,23K07450"],"award-info":[{"award-number":["22K07996,22K08090,23K07450"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Kindai University Research Enhancement","award":["KD2208,KD2301,KD2405"],"award-info":[{"award-number":["KD2208,KD2301,KD2405"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,22]]},"abstract":"<jats:p>\n                    The pathogenesis of the murine model of autoimmune pancreatitis associated with IgG4-related disease (AIP\/IgG4-RD) induced by administration of polyinosinic-polycytidylic acid (poly[I:C]) is incompletely understood. While it is known that murine and human AIP\/IgG4-RD is driven by plasmacytoid dendritic cells (pDCs) producing IFN-\u03b1, the origin of these cells and their relation to effector T cells is not known. Here, we show that murine AIP was initiated by TLR3-bearing conventional DCs in the uninflamed pancreas whose activation by the TLR3 ligand poly(I:C) caused IFN-\u03b1, CXCL9, and CXCL10 secretion. This, in turn, induced pancreatic recruitment of CXCR3\n                    <jats:sup>+<\/jats:sup>\n                    T cells and these T cells, via their secretion of CCL25, facilitated migration of pDCs bearing CCR9 into the pancreas. This established a feedback loop anchored by the now dominant pDC production of IFN-\u03b1 and the continued CXCR3\n                    <jats:sup>+<\/jats:sup>\n                    T cell facilitation of pDC migration. Remarkably, the interaction between CXCR3\n                    <jats:sup>+<\/jats:sup>\n                    T cells and pDCs also existed at the functional level since this interaction enhanced the production of CCL25 and IFN-\u03b1 by CXCR3\n                    <jats:sup>+<\/jats:sup>\n                    T cells and pDCs, respectively. Evidence presented here that a similar disease mechanism was present in human AIP\/IgG4-RD creates new avenues of disease treatment.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.167910","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T12:31:51Z","timestamp":1726144311000},"source":"Crossref","is-referenced-by-count":26,"title":["A positive cytokine\/chemokine feedback loop establishes plasmacytoid DC\u2013driven autoimmune pancreatitis in IgG4-related disease"],"prefix":"10.1172","volume":"9","author":[{"given":"Akane","family":"Hara","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Minaga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoe","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kurimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikue","family":"Sekai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Masuta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryutaro","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kamata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6681-0258","authenticated-orcid":true,"given":"Shiki","family":"Takamura","sequence":"additional","affiliation":[{"name":"Laboratory for Immunological Memory, RIKEN IMS Center for Integrative Medical Science, Yokohama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Strober","sequence":"additional","affiliation":[{"name":"Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1104650"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60720-0"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.09.005"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500971"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700060"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-020-01662-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71848-4"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323797"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209139"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201477"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/art.39209"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/art.33320"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/art.40556"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601507"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-020-00361-0"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3757015"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1330"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4492"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1021\/ja111312h"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.01.012"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nri3865"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.024"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.039"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.05.007"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.07.001"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxz050"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.153"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13509"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39481"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.2.219"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1901358"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29782"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314832"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxac039"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-020-00158-4"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.10.009"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230667"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00693-5"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.07.005"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300675"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310336"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaq0997"},{"issue":"4","key":"B44","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/gutjnl-2017-314548","article-title":"Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease","volume":"67","author":"Hubers","year":"2018","journal-title":"Gut"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03207.x"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxz045"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.144"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2017.1290911"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001443"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0242-4"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/167910\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:38:31Z","timestamp":1779136711000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/167910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":50,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2024,10,22]]},"published-print":{"date-parts":[[2024,10,22]]}},"alternative-id":["10.1172\/jci.insight.167910"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.167910","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,12]]},"article-number":"e167910"}}