{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:33:39Z","timestamp":1793205219720,"version":"4.5.0"},"reference-count":71,"publisher":"American Society for Clinical Investigation","issue":"12","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"crossref","award":["Start-up funds to DS"],"award-info":[{"award-number":["Start-up funds to DS"]}],"id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"crossref","award":["Jennifer Salvitti Davis MD Chair Professorship in Ophthalmology to DS"],"award-info":[{"award-number":["Jennifer Salvitti Davis MD Chair Professorship in Ophthalmology to DS"]}],"id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"crossref","award":["To Department of Ophthalmology,"],"award-info":[{"award-number":["To Department of Ophthalmology,"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"crossref","award":["To DS"],"award-info":[{"award-number":["To DS"]}],"id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,22]]},"abstract":"<jats:p>\n                    Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults and remains an important public health issue worldwide. Here we demonstrate that the expression of stimulator of interferon genes (STING) is increased in patients with DR and animal models of diabetic eye disease. STING has been previously shown to regulate cell senescence and inflammation, key contributors to the development and progression of DR. To investigate the mechanism whereby STING contributes to the pathogenesis of DR, diabetes was induced in\n                    <jats:italic>STING<\/jats:italic>\n                    -KO mice and\n                    <jats:italic>STING<\/jats:italic>\n                    <jats:sup>GT<\/jats:sup>\n                    (loss-of-function mutation) mice, and molecular alterations and pathological changes in the retina were characterized. We report that retinal endothelial cell senescence, inflammation, and capillary degeneration were all inhibited in\n                    <jats:italic>STING<\/jats:italic>\n                    -KO diabetic mice; these observations were independently corroborated in\n                    <jats:italic>STING<\/jats:italic>\n                    <jats:sup>GT<\/jats:sup>\n                    mice. These protective effects resulted from the reduction in TBK1, IRF3, and NF-\u03baB phosphorylation in the absence of STING. Collectively, our results suggest that targeting STING may be an effective therapy for the early prevention and treatment of DR.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.168945","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T14:05:15Z","timestamp":1687356315000},"source":"Crossref","is-referenced-by-count":104,"title":["Activated cGAS\/STING signaling elicits endothelial cell senescence in early diabetic retinopathy"],"prefix":"10.1172","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3757-779X","authenticated-orcid":true,"given":"Haitao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayan","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanuja","family":"Vaidya","sequence":"additional","affiliation":[{"name":"GROW Laboratory, Narayana Nethralaya Foundation, Bengaluru, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3189-6140","authenticated-orcid":true,"given":"Sridhar","family":"Bammidi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[{"name":"Pharma Research and Early Development, Roche Innovation Center Basel, F. 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