{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:10Z","timestamp":1792787590716,"version":"4.5.0"},"reference-count":57,"publisher":"American Society for Clinical Investigation","issue":"3","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["1R01AR075864-01A1"],"award-info":[{"award-number":["1R01AR075864-01A1"]}]},{"DOI":"10.13039\/100007100","name":"Sandler Foundation","doi-asserted-by":"crossref","award":["7000\/7002124"],"award-info":[{"award-number":["7000\/7002124"]}],"id":[{"id":"10.13039\/100007100","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Trex Bio","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/100010878","name":"AbbVie Biotherapeutics","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100010878","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012331","name":"LEO Fondet","doi-asserted-by":"crossref","award":["LF-OC-23-001147"],"award-info":[{"award-number":["LF-OC-23-001147"]}],"id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,8]]},"abstract":"<jats:p>Hidradenitis suppurativa (HS) is a chronic skin condition affecting approximately 1% of the US population. HS skin lesions are highly inflammatory and characterized by a large immune infiltrate. While B cells and plasma cells comprise a major component of this immune milieu, the biology and the contribution of these cells in HS pathogenesis are unclear. We aimed to investigate the dynamics and microenvironmental interactions of B cells within cutaneous HS lesions. Combining histological analysis, single-cell RNA sequencing, and spatial transcriptomics profiling of HS lesions, we defined the tissue microenvironment relative to B cell activity within this disease. Our findings identified tertiary lymphoid structures (TLSs) within HS lesions and described organized interactions among T cells, B cells, antigen-presenting cells, and skin stroma. We found evidence that B cells within HS TLSs actively underwent maturation, including participation in germinal center reactions and class switch recombination. Moreover, skin stroma and accumulating T cells were primed to support the formation of TLSs and facilitate B cell recruitment during HS. Our data definitively demonstrated the presence of TLSs in lesional HS skin and point to ongoing cutaneous B cell maturation through class switch recombination and affinity maturation during disease progression in this inflamed nonlymphoid tissue.<\/jats:p>","DOI":"10.1172\/jci.insight.169870","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T12:00:23Z","timestamp":1702987223000},"source":"Crossref","is-referenced-by-count":42,"title":["Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa"],"prefix":"10.1172","volume":"9","author":[{"given":"Margaret M.","family":"Lowe","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of California, San Francisco (UCSF), San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarish N.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San 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