{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:27Z","timestamp":1792787607899,"version":"4.5.0"},"reference-count":37,"publisher":"American Society for Clinical Investigation","issue":"9","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"WISE","award":["PSIA2020AGDG-3316"],"award-info":[{"award-number":["PSIA2020AGDG-3316"]}]},{"name":"NIH","award":["5R44AI055229"],"award-info":[{"award-number":["5R44AI055229"]}]},{"name":"NIH","award":["5R44AI058375"],"award-info":[{"award-number":["5R44AI058375"]}]},{"name":"NIH","award":["U01A165745"],"award-info":[{"award-number":["U01A165745"]}]},{"name":"EDCTP2","award":["RIA2018SV-2310"],"award-info":[{"award-number":["RIA2018SV-2310"]}]},{"DOI":"10.13039\/100009139","name":"DZIF","doi-asserted-by":"crossref","award":["DZIF TTU 03.802"],"award-info":[{"award-number":["DZIF TTU 03.802"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,8]]},"abstract":"<jats:p>\n                    Vaccination of malaria-naive volunteers with a high dose of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    sporozoites chemoattenuated by chloroquine (CQ) (PfSPZ-CVac [CQ]) has previously demonstrated full protection against controlled human malaria infection (CHMI). However, lower doses of PfSPZ-CVac [CQ] resulted in incomplete protection. This provides the opportunity to understand the immune mechanisms needed for better vaccine-induced protection by comparing individuals who were protected with those not protected. Using mass cytometry, we characterized immune cell composition and responses of malaria-naive European volunteers who received either lower doses of PfSPZ-CVac [CQ], resulting in 50% protection irrespective of the dose, or a placebo vaccination, with everyone becoming infected following CHMI. Clusters of CD4\n                    <jats:sup>+<\/jats:sup>\n                    and \u03b3\u03b4 T cells associated with protection were identified, consistent with their known role in malaria immunity. Additionally, EMRA CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and CD56\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell clusters were associated with protection. In a cohort from a malaria-endemic area in Gabon, these CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell clusters were also associated with parasitemia control in individuals with lifelong exposure to malaria. Upon stimulation with\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>falciparum<\/jats:italic>\n                    \u2013infected erythrocytes, CD4\n                    <jats:sup>+<\/jats:sup>\n                    , \u03b3\u03b4, and EMRA CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells produced IFN-\u03b3 and\/or TNF, indicating their ability to mediate responses that eliminate malaria parasites.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.170210","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T14:00:34Z","timestamp":1715090434000},"source":"Crossref","is-referenced-by-count":4,"title":["Immune responses associated with protection induced by chemoattenuated PfSPZ vaccine in malaria-naive Europeans"],"prefix":"10.1172","volume":"9","author":[{"given":"Yoanne D.","family":"Mouwenda","sequence":"first","affiliation":[{"name":"Centre de Recherches 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