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Here, we investigated the effect of supporting respiratory function via continuous positive airway pressure (CPAP) on glymphatic-lymphatic function in spontaneously breathing anesthetized rodents. To do this, we used a systems approach combining engineering, MRI, computational fluid dynamics analysis, and physiological testing. We first designed a nasal CPAP device for use in the rat and demonstrated that it functioned similarly to clinical devices, as evidenced by its ability to open the upper airway, augment end-expiratory lung volume, and improve arterial oxygenation. We further showed that CPAP increased CSF flow speed at the skull base and augmented glymphatic transport regionally. The CPAP-induced augmented CSF flow speed was associated with an increase in intracranial pressure (ICP), including the ICP waveform pulse amplitude. We suggest that the augmented pulse amplitude with CPAP underlies the increase in CSF bulk flow and glymphatic transport. Our results provide insights into the functional crosstalk at the pulmonary-CSF interface and suggest that CPAP might have therapeutic benefit for sustaining glymphatic-lymphatic function.<\/jats:p>","DOI":"10.1172\/jci.insight.170270","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T12:24:27Z","timestamp":1683635067000},"source":"Crossref","is-referenced-by-count":53,"title":["Continuous positive airway pressure increases CSF flow and glymphatic transport"],"prefix":"10.1172","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2800-2708","authenticated-orcid":true,"given":"Burhan","family":"Ozturk","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Yale School of Medicine, New Haven, Connecticut, 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