{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:10:12Z","timestamp":1791324612884,"version":"4.3.1"},"reference-count":77,"publisher":"American Society for Clinical Investigation","issue":"15","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS090340"],"award-info":[{"award-number":["NS090340"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["19CDA34660056"],"award-info":[{"award-number":["19CDA34660056"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Baylor College of Medicine","award":["Curtis Hankamer Basic Research Fund"],"award-info":[{"award-number":["Curtis Hankamer Basic Research Fund"]}]},{"DOI":"10.13039\/100001454","name":"American Epilepsy Society","doi-asserted-by":"crossref","award":["Junior Investigator Award"],"award-info":[{"award-number":["Junior Investigator Award"]}],"id":[{"id":"10.13039\/100001454","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Blue Bird Circle Foundation","award":["Grant"],"award-info":[{"award-number":["Grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,8]]},"abstract":"<jats:p>\n                    Spreading depolarization (SD) is a massive wave of cellular depolarization that slowly migrates across the brain gray matter. Cortical SD is frequently generated following brain injury, while less is understood about its potential contribution to genetic disorders of hyperexcitability, such as\n                    <jats:italic>SCN1A<\/jats:italic>\n                    -deficient epilepsy, in which febrile seizure often contributes to disease initiation. Here we report that spontaneous SD waves are predominant EEG abnormalities in the\n                    <jats:italic>Scn1a<\/jats:italic>\n                    -deficient mouse (\n                    <jats:italic>\n                      Scn1a\n                      <jats:sup>+\/R1407X<\/jats:sup>\n                    <\/jats:italic>\n                    ) and undergo sustained intensification following a single hyperthermic seizure. Chronic DC-band EEG recording detected spontaneous SDs, seizures, and seizure-SD complexes in\n                    <jats:italic>\n                      Scn1a\n                      <jats:sup>+\/R1407X<\/jats:sup>\n                    <\/jats:italic>\n                    mice but not WT littermates. The SD events were infrequent, while a single hyperthermia-induced seizure robustly increased SD frequency over 4-fold during the initial postictal week. This prolonged neurological aftermath could be suppressed by memantine administration. Video, electromyogram, and EEG spectral analysis revealed distinct neurobehavioral patterns; individual seizures were associated with increased motor activities, while SDs were generally associated with immobility. We also identified a stereotypic SD prodrome, detectable over a minute before the onset of the DC potential shift, characterized by increased motor activity and bilateral EEG frequency changes. Our study suggests that cortical SD is a pathological manifestation in\n                    <jats:italic>SCN1A<\/jats:italic>\n                    -deficient epileptic encephalopathy.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.170399","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T14:00:49Z","timestamp":1691416849000},"source":"Crossref","is-referenced-by-count":20,"title":["A hyperthermic seizure unleashes a surge of spreading depolarizations in Scn1a-deficient mice"],"prefix":"10.1172","volume":"8","author":[{"given":"Isamu","family":"Aiba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey 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