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Nerve Schwann cells (SCs) were recently shown to play roles in nociceptive processing, and we find that chemogenetic activation of SCs is sufficient to induce afferent and behavioral mechanical hypersensitivity in wild-type mice. In mouse models, animals showed afferent and behavioral hypersensitivity when SCs, but not neurons, lacked\n                    <jats:italic>Nf1<\/jats:italic>\n                    . Importantly, hypersensitivity corresponded with SC-specific upregulation of mRNA encoding glial cell line\u2013derived neurotrophic factor (GDNF), independently of the presence of tumors. Neuropathic pain-like behaviors in the NF1 mice were inhibited by either chemogenetic silencing of SC calcium or by systemic delivery of GDNF-targeting antibodies. Together, these findings suggest that alterations in SCs directly modulate mechanical pain and suggest cell-specific treatment strategies to ameliorate pain in individuals with NF1.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.171275","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T14:00:38Z","timestamp":1705932038000},"source":"Crossref","is-referenced-by-count":12,"title":["Schwann cells modulate nociception in neurofibromatosis 1"],"prefix":"10.1172","volume":"9","author":[{"given":"Namrata G.R.","family":"Raut","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Division of Pain Management, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Maile","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Division of Pain Management, Cincinnati Children\u2019s Hospital Medical Center, 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