{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:15:07Z","timestamp":1779142507754,"version":"3.51.4"},"reference-count":81,"publisher":"American Society for Clinical Investigation","issue":"3","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AR052646,NS047726,"],"award-info":[{"award-number":["AR052646,NS047726,"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL061322"],"award-info":[{"award-number":["HL061322"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005693","name":"Parent Project Muscular Dystrophy","doi-asserted-by":"crossref","award":["X"],"award-info":[{"award-number":["X"]}],"id":[{"id":"10.13039\/100005693","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,8]]},"abstract":"<jats:p>\n                    The Murphy Roths Large (MRL) mouse strain has \u201csuper-healing\u201d properties that enhance recovery from injury. In mice, the DBA\/2J strain intensifies many aspects of muscular dystrophy, so we evaluated the ability of the MRL strain to suppress muscular dystrophy in the\n                    <jats:italic>Sgcg<\/jats:italic>\n                    -null mouse model of limb girdle muscular dystrophy. A comparative analysis of\n                    <jats:italic>Sgcg<\/jats:italic>\n                    -null mice in the DBA\/2J versus MRL strains showed greater myofiber regeneration, with reduced structural degradation of muscle in the MRL strain. Transcriptomic profiling of dystrophic muscle indicated strain-dependent expression of extracellular matrix (ECM) and TGF-\u03b2 signaling genes. To investigate the MRL ECM, cellular components were removed from dystrophic muscle sections to generate decellularized myoscaffolds. Decellularized myoscaffolds from dystrophic mice in the protective MRL strain had significantly less deposition of collagen and matrix-bound TGF-\u03b21 and TGF-\u03b23 throughout the matrix. Dystrophic myoscaffolds from the MRL background, but not the DBA\/2J background, were enriched in myokines like IGF-1 and IL-6. C2C12 myoblasts seeded onto decellularized matrices from\n                    <jats:italic>\n                      Sgcg\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    MRL and\n                    <jats:italic>\n                      Sgcg\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    DBA\/2J muscles showed the MRL background induced greater myoblast differentiation compared with dystrophic DBA\/2J myoscaffolds. Thus, the MRL background imparts its effect through a highly regenerative ECM, which is active even in muscular dystrophy.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.173246","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T12:00:42Z","timestamp":1704369642000},"source":"Crossref","is-referenced-by-count":1,"title":["The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix"],"prefix":"10.1172","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3814-3608","authenticated-orcid":true,"given":"Joseph G.","family":"O\u2019Brien","sequence":"first","affiliation":[{"name":"Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander B.","family":"Willis","sequence":"additional","affiliation":[{"name":"Center for Genetic Medicine, Northwestern 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