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Previous reports of\n                    <jats:italic>\n                      FGF15\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice have limited our understanding of gut-specific FGF15\u2019s role in metabolism. Therefore, we studied the role of endogenous gut-derived FGF15 in bile acid, cholesterol, glucose, and energy balance. We found that circulating levels of FGF19 were reduced in individuals with obesity and comorbidities, such as type 2 diabetes and metabolic dysfunction\u2013associated fatty liver disease. Gene expression analysis of ileal FGF15-positive cells revealed differential expression during the obesogenic state. We fed standard chow or a high-fat metabolic dysfunction-associated steatohepatitis\u2013inducing diet to control and intestine-derived FGF15-knockout (FGF15\n                    <jats:sup>INT-KO<\/jats:sup>\n                    ) mice. Control and FGF15\n                    <jats:sup>INT-KO<\/jats:sup>\n                    mice gained similar body weight and adiposity and did not show genotype-specific differences in glucose, mixed meal, pyruvate, and glycerol tolerance. FGF15\n                    <jats:sup>INT-KO<\/jats:sup>\n                    mice had increased systemic bile acid levels but decreased cholesterol levels, pointing to a primary role for gut-derived FGF15 in regulating bile acid and cholesterol metabolism when exposed to obesogenic diet. These studies show that intestinal FGF15 plays a specific role in bile acid and cholesterol metabolism regulation but is not essential for energy and glucose balance.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.174164","type":"journal-article","created":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T14:00:31Z","timestamp":1712498431000},"source":"Crossref","is-referenced-by-count":30,"title":["Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance"],"prefix":"10.1172","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-2916","authenticated-orcid":true,"given":"Nadejda","family":"Bozadjieva-Kramer","sequence":"first","affiliation":[{"name":"Research Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, USA."},{"name":"Department of Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae 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