{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:12:10Z","timestamp":1779142330871,"version":"3.51.4"},"reference-count":61,"publisher":"American Society for Clinical Investigation","issue":"6","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["R01DK135621,R01HL122770,R35HL155008,1P20GM130459,R01DK101997,R01DK083042,R01DK089056,R01DK124238,P30DK017047"],"award-info":[{"award-number":["R01DK135621,R01HL122770,R35HL155008,1P20GM130459,R01DK101997,R01DK083042,R01DK089056,R01DK124238,P30DK017047"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,22]]},"abstract":"<jats:p>\n                    Glucose homeostasis is achieved via complex interactions between the endocrine pancreas and other peripheral tissues and glucoregulatory neurocircuits in the brain that remain incompletely defined. Within the brain, neurons in the hypothalamus appear to play a particularly important role. Consistent with this notion, we report evidence that (pro)renin receptor (PRR) signaling within a subset of tyrosine hydroxylase (TH) neurons located in the hypothalamic paraventricular nucleus (PVN\n                    <jats:sup>TH<\/jats:sup>\n                    neurons) is a physiological determinant of the defended blood glucose level. Specifically, we demonstrate that PRR deletion from PVN\n                    <jats:sup>TH<\/jats:sup>\n                    neurons restores normal glucose homeostasis in mice with diet-induced obesity (DIO). Conversely, chemogenetic inhibition of PVN\n                    <jats:sup>TH<\/jats:sup>\n                    neurons mimics the deleterious effect of DIO on glucose. Combined with our finding that PRR activation inhibits PVN\n                    <jats:sup>TH<\/jats:sup>\n                    neurons, these findings suggest that, in mice, (a) PVN\n                    <jats:sup>TH<\/jats:sup>\n                    neurons play a physiological role in glucose homeostasis, (b) PRR activation impairs glucose homeostasis by inhibiting these neurons, and (c) this mechanism plays a causal role in obesity-associated metabolic impairment.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.174294","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T12:00:49Z","timestamp":1707825649000},"source":"Crossref","is-referenced-by-count":3,"title":["(Pro)renin receptor signaling in hypothalamic tyrosine hydroxylase neurons is required for obesity-associated glucose metabolic impairment"],"prefix":"10.1172","volume":"9","author":[{"given":"Shiyue","family":"Pan","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and Physiology & Cell Biology and"},{"name":"Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno, Reno, Nevada, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"A.C. 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