{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:46:06Z","timestamp":1793245566861,"version":"4.5.0"},"reference-count":62,"publisher":"American Society for Clinical Investigation","issue":"16","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["1K08AR079593,5R01AI103867,U19AI057229,P30-AR073752"],"award-info":[{"award-number":["1K08AR079593,5R01AI103867,U19AI057229,P30-AR073752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"crossref","award":["Scientist Development Award"],"award-info":[{"award-number":["Scientist Development Award"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000964","name":"Arthritis National Research Foundation","doi-asserted-by":"crossref","award":["Award in Ankylosing Spondylitis"],"award-info":[{"award-number":["Award in Ankylosing Spondylitis"]}],"id":[{"id":"10.13039\/100000964","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","award":["MR\/M019837\/1"],"award-info":[{"award-number":["MR\/M019837\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"crossref","award":["M455"],"award-info":[{"award-number":["M455"]}],"id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,22]]},"abstract":"<jats:p>\n                    HLA-B*27 was one of the first HLA alleles associated with an autoimmune disease, i.e., axial spondyloarthritis (axSpA) and acute anterior uveitis (B27AAU), which cause joint and eye inflammation, respectively. Gastrointestinal inflammation has been suggested as a trigger of axSpA. We recently identified a bacterial peptide (YeiH) that can be presented by HLA-B*27 to expanded public T cell receptors in the joint in axSpA and the eye in B27AAU. While YeiH is present in enteric microbiota and pathogens, additional evidence that pathogenic T cells in HLA-B*27\u2013associated autoimmunity may have had a prior antigenic encounter within the gastrointestinal tract remains lacking. Here, we analyzed ocular, synovial, and blood T cells in B27AAU and axSpA, showing that YeiH-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells express a mucosal gene set and surface proteins consistent with intestinal differentiation, including CD161, integrin \u03b14\u03b27, and CCR6. In addition, we found an expansion of YeiH-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in axSpA and B27AAU blood compared with that from individuals acting as healthy controls, whereas influenza-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells were equivalent across groups. Finally, we demonstrated the dispensability of TRBV9 for antigen recognition. Collectively, our data suggest that, in HLA-B27\u2013associated autoimmunity, early antigen exposure and differentiation of pathogenic CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells may occur in enteric organs.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.174776","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T12:00:34Z","timestamp":1721304034000},"source":"Crossref","is-referenced-by-count":25,"title":["Mucosal signatures of pathogenic T cells in HLA-B*27+ anterior uveitis and axial spondyloarthritis"],"prefix":"10.1172","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-3176","authenticated-orcid":true,"given":"Michael A.","family":"Paley","sequence":"first","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Yang","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9939-9071","authenticated-orcid":true,"given":"Lynn M.","family":"Hassman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-8576","authenticated-orcid":true,"given":"Frank","family":"Penkava","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Science, Botnar Research Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee I.","family":"Garner","sequence":"additional","affiliation":[{"name":"NDM Research Building, Nuffield Department of Medicine, and"},{"name":"Centre for Immuno-oncology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4892-4195","authenticated-orcid":true,"given":"Grace L.","family":"Paley","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Linskey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Agnew","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Henrique","family":"Arantes de Faria","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Simone","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Science, Botnar Research Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5921-2399","authenticated-orcid":true,"given":"Elisha D.O.","family":"Roberson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."},{"name":"Department of Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3520-6407","authenticated-orcid":true,"given":"Philip A.","family":"Ruzycki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA."},{"name":"Department of Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9806-662X","authenticated-orcid":true,"given":"Ekaterina","family":"Esaulova","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Laurent","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lacey","family":"Feigl-Lenzen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke E.","family":"Springer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine M.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"NDM Research Building, Nuffield Department of Medicine, and"},{"name":"Centre for Immuno-oncology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bowness","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Science, Botnar Research Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9273-0278","authenticated-orcid":true,"given":"K. Christopher","family":"Garcia","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, California, USA."},{"name":"Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0566-7264","authenticated-orcid":true,"given":"Wayne M.","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."},{"name":"Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00552-4"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197304052881403"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/ng.873"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2015-000053"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91360-3"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199807000-00006"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2011.559302"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.03.049"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2005.04.003"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00080"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112110"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/art.24763"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/XXVII.suppl_2.95"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1086\/322644"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.027524"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0097-2"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05501-7"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02613-z"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.47360\/1995-4484-2024-65-80"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0444-8"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208902"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2019.1686156"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801091"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.69"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.09.045"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108661"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/art.40028"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/art.41252"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.07.032"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062376"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2008.84"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab019"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.608134"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215734"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215739"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.973243"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.7.3830"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43036-1"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/fevsoy"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112514"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.10.005"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.932393"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1639-3"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/art.33507"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.151133"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01610"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206323"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.22.2131"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021933"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.1"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.03.049"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1136\/mp.52.5.300"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02931-3"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2021.100010"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2022.577860"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2019.03.003"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1874-1"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01625-6"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101590"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/174776\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:41:40Z","timestamp":1779136900000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/174776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,18]]},"references-count":62,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,7,18]]},"published-print":{"date-parts":[[2024,8,22]]}},"alternative-id":["10.1172\/jci.insight.174776"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.174776","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,18]]},"article-number":"e174776"}}