{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:11:38Z","timestamp":1779142298385,"version":"3.51.4"},"reference-count":59,"publisher":"American Society for Clinical Investigation","issue":"9","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,8]]},"abstract":"<jats:p>\n                    People with HIV (PWH) have a higher age-adjusted mortality due to chronic immune activation and age-related comorbidities. PWH also have higher rates of clonal hematopoiesis (CH) than age-matched non-HIV cohorts; however, risk factors influencing the development and expansion of CH in PWH remain incompletely explored. We investigated the relationship between CH, immune biomarkers, and HIV-associated risk factors (CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, nadir CD4\n                    <jats:sup>+<\/jats:sup>\n                    count, opportunistic infections [OIs], and immune reconstitution inflammatory syndrome [IRIS]) in a diverse cohort of 197 PWH with median age of 42 years, using a 56-gene panel. Seventy-nine percent had a CD4\n                    <jats:sup>+<\/jats:sup>\n                    nadir below 200 cells\/\u03bcL, 58.9% had prior OIs, and 34.5% had a history of IRIS. The prevalence of CH was high (27.4%), even in younger individuals, and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and nadir CD4\n                    <jats:sup>+<\/jats:sup>\n                    counts strongly associated with CH after controlling for age. A history of IRIS was associated with CH in a subgroup analysis of patients 35 years of age and older. Inflammatory biomarkers were higher in CH carriers compared with noncarriers, supporting a dysregulated immune state. These findings suggest PWH with low nadir CD4\n                    <jats:sup>+<\/jats:sup>\n                    and\/or inflammatory complications may be at high risk of CH regardless of age and represent a high-risk group that could benefit from risk reduction and potentially targeted immunomodulation.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.174783","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T12:01:44Z","timestamp":1712059304000},"source":"Crossref","is-referenced-by-count":9,"title":["Clonal hematopoiesis in people with advanced HIV and associated inflammatory syndromes"],"prefix":"10.1172","volume":"9","author":[{"given":"Joseph M.","family":"Rocco","sequence":"first","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Translational Stem Cell Biology Branch, 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