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Chronic airway inflammation in CF contributes to morbidity and mortality, and aging processes like inflammaging and cell senescence influence CF pathology. Our results show that single-cell RNA sequencing data, human primary bronchial epithelial cells from non-CF and CF donors, a CF bronchial epithelial cell line, and\n                    <jats:italic>Cftr<\/jats:italic>\n                    -knockout (\n                    <jats:italic>\n                      Cftr\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    ) rats all demonstrated increased cell senescence markers in the CF bronchial epithelium. This was associated with upregulation of fibroblast growth factor receptors (FGFRs) and mitogen-activated protein kinase (MAPK) p38. Inhibition of FGFRs, specifically FGFR4 and to some extent FGFR1, attenuated cell senescence and improved mucociliary clearance, which was associated with MAPK p38 signaling. Mucociliary dysfunction could also be improved using a combination of senolytics in a CF ex vivo model. In summary, FGFR\/MAPK p38 signaling contributes to cell senescence in CF airways, which is associated with impaired mucociliary clearance. Therefore, attenuation of cell senescence in the CF airways might be a future therapeutic strategy improving mucociliary dysfunction and lung disease in an aging population with CF.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.174888","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T12:00:16Z","timestamp":1719316816000},"source":"Crossref","is-referenced-by-count":9,"title":["FGF receptors mediate cellular senescence in the cystic fibrosis airway epithelium"],"prefix":"10.1172","volume":"9","author":[{"given":"Molly","family":"Easter","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan June","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Department of 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