{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:05:01Z","timestamp":1783713901355,"version":"3.55.0"},"reference-count":46,"publisher":"American Society for Clinical Investigation","issue":"17","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82172023,82202252,82302292"],"award-info":[{"award-number":["82172023,82202252,82302292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFC3500603"],"award-info":[{"award-number":["2022YFC3500603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Basic Research Program of Shaanxi","award":["2022JC-44,2022JQ-622,2023-JC-QN-0922,2023-ZDLSF-07"],"award-info":[{"award-number":["2022JC-44,2022JQ-622,2023-JC-QN-0922,2023-ZDLSF-07"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["ZYTS23188,XJSJ23190,XJS221201,QTZX23093"],"award-info":[{"award-number":["ZYTS23188,XJSJ23190,XJS221201,QTZX23093"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Intramural Research Program of the National Institute on Alcoholism and Alcohol Abuse","award":["Y1AA3009"],"award-info":[{"award-number":["Y1AA3009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>A polymorphism in the fat mass and obesity-associated gene (FTO) is linked to enhanced neural sensitivity to food cues and attenuated ghrelin suppression. Risk allele carriers regain more weight than noncarriers after bariatric surgery. It remains unclear how FTO variation affects brain function and ghrelin following surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Resting-state functional magnetic resonance imaging and cue-reactivity functional magnetic resonance imaging with high-\/low-caloric food cues were performed before surgery and at 1, 6, and 12 months after surgery to examine brain function in 16 carriers with 1 copy of the rs9939609 A allele (AT) and 26 noncarriers (TT). Behavioral assessments up to 5 years after surgery were also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The AT group relative to the TT group had smaller BMI loss at 12\u201360 months after surgery and lower resting-state activity in posterior cingulate cortex following laparoscopic sleeve gastrectomy (group-by-time interaction effects). Meanwhile, the AT group relative to the TT group showed greater food cue responses in dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), and insula (group effects). There were negative associations of weight loss with ghrelin and greater activation in DLPFC, DMPFC and insula in the AT but not the TT group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>These findings indicate that FTO variation is associated with the evolution of ghrelin signaling and brain function after bariatric surgery, which might hinder weight loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry Center, ChiCTR-OOB-15006346.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>FUNDING<\/jats:title>\n                    <jats:p>This work was supported by the National Natural Science Foundation of China (grant nos. 82172023, 82202252, 82302292); National Key R&amp;D Program of China (no. 2022YFC3500603); Natural Science Basic Research Program of Shaanxi (grant nos. 2022JC-44, 2022JQ-622, 2023-JC-QN-0922, 2023-ZDLSF-07); Fundamental Research Funds for the Central Universities (grant nos. ZYTS23188, XJSJ23190, XJS221201, QTZX23093); and the Intramural Research Program of the National Institute on Alcoholism and Alcohol Abuse (grant no. Y1AA3009).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1172\/jci.insight.175967","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T12:00:52Z","timestamp":1722513652000},"source":"Crossref","is-referenced-by-count":4,"title":["FTO variant is associated with changes in BMI, ghrelin, and brain function following bariatric surgery"],"prefix":"10.1172","volume":"9","author":[{"given":"Guanya","family":"Li","sequence":"first","affiliation":[{"name":"Center for Brain Imaging, School of Life Science and Technology, Xidian University and Engineering Research Center of Molecular and Neuroimaging, Ministry of Education, Xi\u2019an, Shaanxi, China."},{"name":"International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment and Xi\u2019an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, School of Life Science and Technology, Xidian University, Xi\u2019an, Shaanxi, 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Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment and Xi\u2019an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, School of Life Science and Technology, Xidian University, Xi\u2019an, Shaanxi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Brain Imaging, School of Life Science and Technology, Xidian University and Engineering Research Center of Molecular and Neuroimaging, Ministry of Education, Xi\u2019an, Shaanxi, China."},{"name":"International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment and Xi\u2019an Key Laboratory of Intelligent Sensing and Regulation of Trans-Scale Life Information, School of Life Science and Technology, Xidian University, Xi\u2019an, Shaanxi, 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