{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:27:19Z","timestamp":1786444039521,"version":"build-2736575974"},"reference-count":67,"publisher":"American Society for Clinical Investigation","issue":"6","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Chinese National Science Foundation","doi-asserted-by":"crossref","award":["82172629,81871936,81702747"],"award-info":[{"award-number":["82172629,81871936,81702747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,22]]},"abstract":"<jats:p>\n                    Suppressor of fused (SUFU) is widely regarded as a key negative regulator of the sonic hedgehog (SHH) morphogenic pathway and a known tumor suppressor of medulloblastoma (MB). However, we report here that SUFU expression was markedly increased in 75% of specimens compiled in a tissue array comprising 49 unstratified MBs. The SUFU and GLI1 expression levels in this MB array showed strong positive correlation, which was also identified in a large public data set containing 736 MBs. We further report that increasing\n                    <jats:italic>Sufu<\/jats:italic>\n                    gene dosage in mice caused preaxial polydactyly, which was associated with the expansion of the Gli3 domain in the anterior limb bud and heightened Shh signaling responses during embryonic development. Increasing\n                    <jats:italic>Sufu<\/jats:italic>\n                    gene dosage also led to accelerated cerebellar development and, when combined with ablation of the Shh receptor encoded by\n                    <jats:italic>Patched1<\/jats:italic>\n                    (\n                    <jats:italic>Ptch1<\/jats:italic>\n                    ), promoted MB tumorigenesis. These data reveal multifaceted roles of\n                    <jats:italic>SUFU<\/jats:italic>\n                    in promoting MB tumorigenesis by enhancing SHH signaling. This revelation clarifies potentially counterintuitive clinical observation of high SUFU expression in MBs and may pave way for novel strategies to reduce or reverse MB progression.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.176044","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T12:00:28Z","timestamp":1707998428000},"source":"Crossref","is-referenced-by-count":3,"title":["Increasing Sufu gene dosage reveals its unorthodox role in promoting polydactyly and medulloblastoma tumorigenesis"],"prefix":"10.1172","volume":"9","author":[{"given":"Boang","family":"Han","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Nanjing Medical University, Nanjing, 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