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Its role in immune regulation has been implicated in murine models and human genome-wide association studies, suggesting defective DCIR function associates with increased susceptibility to autoimmune diseases such as rheumatoid arthritis, lupus, and Sj\u00f6gren\u2019s syndrome. However, little is known about the mechanisms underlying DCIR activation to dampen inflammation. Here, we developed anti-DCIR agonistic antibodies that promote phosphorylation on DCIR\u2019s immunoreceptor tyrosine-based inhibitory motifs and recruitment of SH2 containing protein tyrosine phosphatase-2 for reducing inflammation. We also explored the inflammation resolution by depleting DCIR\n                    <jats:sup>+<\/jats:sup>\n                    cells with antibodies. Utilizing a human DCIR\u2013knock-in mouse model, we validated the antiinflammatory properties of the agonistic anti-DCIR antibody in experimental peritonitis and colitis. These findings provide critical evidence for targeting DCIR to develop transformative therapies for inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.176064","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T12:00:34Z","timestamp":1716465634000},"source":"Crossref","is-referenced-by-count":3,"title":["Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution"],"prefix":"10.1172","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-8883","authenticated-orcid":true,"given":"Liang","family":"Chen","sequence":"first","affiliation":[{"name":"AbbVie, Cambridge Research Center, Cambridge, Massachusetts, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Patil","sequence":"additional","affiliation":[{"name":"AbbVie, Cambridge Research Center, Cambridge, Massachusetts, 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