{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:59:57Z","timestamp":1789430397483,"version":"build-2803163510"},"reference-count":55,"publisher":"American Society for Clinical Investigation","issue":"15","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Psoriasis Foundation, National Institute of Health, NCI","award":["MLG-H (NPF851079),CTR (NPF2017DG01),CTR (AR0169000),JR-M (R01AI111914),(P30CA047904),S10OD028483"],"award-info":[{"award-number":["MLG-H (NPF851079),CTR (NPF2017DG01),CTR (AR0169000),JR-M (R01AI111914),(P30CA047904),S10OD028483"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,8]]},"abstract":"<jats:p>\n                    Psoriatic arthritis (PsA) is a complex inflammatory disease that challenges diagnosis and complicates the rational selection of effective therapies. Although T cells are considered active effectors in psoriasis and PsA, the role of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in pathogenesis is not well understood. We selected the humanized mouse model NSG-SGM3 transgenic strain to examine psoriasis and PsA endotypes. Injection of PBMCs and sera from patients with psoriasis and PsA generated parallel skin and joint phenotypes in the recipient mouse. The transfer of human circulating memory T cells was followed by migration and accumulation in the skin and synovia of these immunodeficient mice. Unexpectedly, immunoglobulins were required for recapitulation of the clinical phenotype of psoriasiform lesions and PsA domains (dactylitis, enthesitis, bone erosion). Human CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells expressing T-bet, IL-32 and CXCL14 were detected by spatial transcriptomics in murine synovia and by immunofluorescence in the human PsA synovia. Importantly, depletion of human CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells prevented skin and synovial inflammation in mice humanized with PsA peripheral blood cells. The humanized model of psoriasis and PsA represents a valid platform for accelerating the understanding of disease pathogenesis, improving the design of personalized therapies, and revealing psoriatic disease targets.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.178213","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T14:01:13Z","timestamp":1723039273000},"source":"Crossref","is-referenced-by-count":16,"title":["Psoriatic arthritis subtypes are phenocopied in humanized mice"],"prefix":"10.1172","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2602-1219","authenticated-orcid":true,"given":"Christopher T.","family":"Ritchlin","sequence":"first","affiliation":[{"name":"University of Rochester Medical Center, Rochester, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9738-1182","authenticated-orcid":true,"given":"Javier","family":"Rangel-Moreno","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, Rochester, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delaney","family":"Martino","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, Rochester, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Isett","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-5307","authenticated-orcid":true,"given":"Ananta","family":"Paine","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, Rochester, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumyaroop","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Fox","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center, University of Rochester Medical Center, Rochester, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest M.","family":"Meyer","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6105-1704","authenticated-orcid":true,"given":"Riyue","family":"Bao","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA."},{"name":"Department of Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullia","family":"Bruno","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA."},{"name":"Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Tausk","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, Rochester, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"de la Luz Garcia-Hernandez","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, Rochester, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1505557"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00776-6"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00874-5"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.06.019"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-013-0377-4"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150805"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-023-01752-w"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.01.001"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03546-14"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13520"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00203"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2020.12.003"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2160-8_5"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1127709"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nri3311"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000446"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2216699119"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/BF00271870"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/art.38376"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39020-4"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0196"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1521s81"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e328337282f"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/v10110643"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.784947"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6621"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151093"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13631"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030297"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47310-5"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/art.41156"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/art.41652"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.138.6.1813"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03933.x"},{"issue":"5","key":"B35","first-page":"1117","article-title":"Predominance of CD8+ T lymphocytes in psoriatic arthritis","volume":"26","author":"Costello","year":"1999","journal-title":"J Rheumatol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.4.2878"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18513-6"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.613204"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.148.2.597"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00380-2"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-015-0083-y"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8413768"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.02.025"},{"issue":"3","key":"B44","first-page":"29","article-title":"Functional role of human interleukin-32 and nuclear transcription factor-kB in patients with psoriasis and psoriatic arthritis","volume":"12","author":"Al-Shobaili","year":"2018","journal-title":"Int J Health Sci (Qassim)"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/ar4089"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-015-0109-9"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1196-6"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1189\/JLB.0109046"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002426"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2022.104655"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abo0686"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1137918"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1159\/000250839"},{"issue":"5 suppl 93","key":"B55","first-page":"S48","article-title":"Disease activity and response assessment in psoriatic arthritis using the Disease Activity index for PSoriatic Arthritis (DAPSA). A brief review","volume":"33","author":"Smolen","year":"2015","journal-title":"Clin Exp Rheumatol"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/178213\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:42:10Z","timestamp":1779136930000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/178213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,2]]},"references-count":55,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,6,25]]},"published-print":{"date-parts":[[2024,8,8]]}},"alternative-id":["10.1172\/jci.insight.178213"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.178213","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,2]]},"article-number":"e178213"}}