{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:43:43Z","timestamp":1791665023832,"version":"4.3.4"},"reference-count":73,"publisher":"American Society for Clinical Investigation","issue":"12","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Veterans Affairs.","award":["I01BX004837,I01BX005750,I01BX003377,I01BX005290"],"award-info":[{"award-number":["I01BX004837,I01BX005750,I01BX003377,I01BX005290"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,24]]},"abstract":"<jats:p>The diffuse axonal damage in white matter and neuronal loss, along with excessive neuroinflammation, hinder long-term functional recovery after traumatic brain injury (TBI). MicroRNAs (miRs) are small noncoding RNAs that negatively regulate protein-coding target genes in a posttranscriptional manner. Recent studies have shown that loss of function of the miR-15a\/16-1 cluster reduced neurovascular damage and improved functional recovery in ischemic stroke and vascular dementia. However, the role of the miR-15a\/16-1 cluster in neurotrauma is poorly explored. Here, we report that genetic deletion of the miR-15a\/16-1 cluster facilitated the recovery of sensorimotor and cognitive functions, alleviated white matter\/gray matter lesions, reduced cerebral glial cell activation, and inhibited infiltration of peripheral blood immune cells to brain parenchyma in a murine model of TBI when compared with WT controls. Moreover, intranasal delivery of the miR-15a\/16-1 antagomir provided similar brain-protective effects conferred by genetic deletion of the miR-15a\/16-1 cluster after experimental TBI, as evidenced by showing improved sensorimotor and cognitive outcomes, better white\/gray matter integrity, and less inflammatory responses than the control antagomir\u2013treated mice after brain trauma. miR-15a\/16-1 genetic deficiency and miR-15a\/16-1 antagomir also significantly suppressed inflammatory mediators in posttrauma brains. These results suggest miR-15a\/16-1 as a potential therapeutic target for TBI.<\/jats:p>","DOI":"10.1172\/jci.insight.178650","type":"journal-article","created":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T14:00:36Z","timestamp":1719151236000},"source":"Crossref","is-referenced-by-count":17,"title":["Loss of microRNA-15a\/16-1 function promotes neuropathological and functional recovery in experimental traumatic brain injury"],"prefix":"10.1172","volume":"9","author":[{"given":"Chao","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."},{"name":"Geriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."},{"name":"Geriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."},{"name":"Geriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA."},{"name":"Geriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton H.","family":"Hamblin","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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