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Recently, eliminating senescent cells has emerged as a promising strategy for treating cancer and for mitigating radiation-induced brain injury (RBI). Here, we investigated the impact of all-\n                    <jats:italic>trans<\/jats:italic>\n                    retinoic acid (RA) on radiation-induced senescence. The findings of this study revealed that RA effectively eliminated astrocytes, which are particularly prone to senescence after radiation, and that the removal of senescence-associated secretory phenotype factor\u2013producing astrocytes inhibited GBM cell proliferation in vitro. Moreover, RA-mediated clearance of senescent cells improved survival in GBM-bearing mice and alleviated radiation-induced cognitive impairment. Through RNA sequencing, we found that the AKT\/mTOR\/PPAR\u03b3\/Plin4 signaling pathway is involved in RA-mediated clearance of senescent cells. In summary, these results suggest that RA could be a potential senolytic drug for preventing GBM progression and improving RBI.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.179530","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T14:00:41Z","timestamp":1730988041000},"source":"Crossref","is-referenced-by-count":11,"title":["All-trans retinoic acid inhibits glioblastoma progression and attenuates radiation-induced brain injury"],"prefix":"10.1172","volume":"9","author":[{"given":"Min","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 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