{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:54:36Z","timestamp":1793904876538,"version":"4.8.0"},"reference-count":102,"publisher":"American Society for Clinical Investigation","issue":"17","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"national institute of mental health","doi-asserted-by":"crossref","award":["R01MH112391,R01DA044584,R01MH131207,R01DA041931,U24MH100931,75N95023C00015,P30MH075673"],"award-info":[{"award-number":["R01MH112391,R01DA044584,R01MH131207,R01DA041931,U24MH100931,75N95023C00015,P30MH075673"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,10]]},"abstract":"<jats:p>\n                    HIV-associated neurocognitive impairment (HIV-NCI) affects 15%\u201350% of people with HIV (PWH), despite viral suppression with antiretroviral therapy (ART). HIV neuropathogenesis is mediated, in part, by transmigration of infected CD14\n                    <jats:sup>+<\/jats:sup>\n                    CD16\n                    <jats:sup>+<\/jats:sup>\n                    monocytes across the blood-brain barrier (BBB) into the central nervous system (CNS). In the CNS, CD14\n                    <jats:sup>+<\/jats:sup>\n                    CD16\n                    <jats:sup>+<\/jats:sup>\n                    monocytes contribute to infection and activation of parenchymal cells, resulting in production of neurotoxic viral and host factors that cause neuronal damage. Mechanisms by which CD14\n                    <jats:sup>+<\/jats:sup>\n                    CD16\n                    <jats:sup>+<\/jats:sup>\n                    monocytes contribute to HIV-NCI have not been characterized in a study population of PWH on ART without contribution from confounders that affect cognition (e.g., substance use, hepatitis C virus coinfection). We assessed cognitive function, PBMC transmigration across the BBB, and neuronal health markers in a well-defined cohort of 56 PWH on ART using stringent criteria to eliminate confounding factors. We demonstrated that PWH on ART with HIV-NCI have significantly increased transmigration of their CD14\n                    <jats:sup>+<\/jats:sup>\n                    CD16\n                    <jats:sup>+<\/jats:sup>\n                    monocytes across the BBB compared with those with normal cognition. We showed that hypertension and diabetes may be effect modifiers on the association between CD14\n                    <jats:sup>+<\/jats:sup>\n                    CD16\n                    <jats:sup>+<\/jats:sup>\n                    monocyte transmigration and cognition. This study underscored the persistent role of CD14\n                    <jats:sup>+<\/jats:sup>\n                    CD16\n                    <jats:sup>+<\/jats:sup>\n                    monocytes in HIV-NCI, even in PWH with viral suppression, suggesting them as potential targets for therapeutic interventions.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.179855","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T15:05:51Z","timestamp":1726067151000},"source":"Crossref","is-referenced-by-count":18,"title":["CD14+CD16+ monocyte transmigration across the blood-brain barrier is associated with HIV-NCI despite viral suppression"],"prefix":"10.1172","volume":"9","author":[{"given":"Veronica","family":"Veksler","sequence":"first","affiliation":[{"name":"Department of Pathology, Albert Einstein College of Medicine, New York, New York, 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