{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:00:05Z","timestamp":1793156405088,"version":"4.5.0"},"reference-count":51,"publisher":"American Society for Clinical Investigation","issue":"20","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01-AR079483"],"award-info":[{"award-number":["R01-AR079483"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"crossref","award":["I01RX002701"],"award-info":[{"award-number":["I01RX002701"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100016935","name":"Lisa Dean Moseley Foundation","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100016935","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001582","name":"Dermatology Foundation","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100001582","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,22]]},"abstract":"<jats:p>\n                    Lichen planus (LP) is a chronic, debilitating, inflammatory disease of the skin and mucous membranes that affects 1%\u20132% of Americans. Its molecular pathogenesis remains poorly understood, and there are no FDA-approved treatments. We performed single-cell RNA sequencing on paired blood and skin samples (lesional and nonlesional tissue) from 7 patients with LP. We discovered that LP keratinocytes and fibroblasts specifically secrete a combination of CXCL9, CXCL10, and CCL19 cytokines. Using an in vitro migration assay with primary human T cells, we demonstrated that CCL19 in combination with either of the other 2 cytokines synergistically enhanced recruitment of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells more than any individual cytokine. Moreover, exhausted T cells in lesional LP skin secreted CXCL13, which, along with CCL19, also enhanced recruitment of T cells, suggesting a feed-forward loop in LP. Finally, LP blood revealed decreased circulating naive CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells compared with that in healthy volunteers, consistent with recruitment to skin. Molecular analysis of LP skin and blood samples increased our understanding of disease pathogenesis and identified CCL19 as a new therapeutic target for treatment.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.179899","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T12:00:42Z","timestamp":1724760042000},"source":"Crossref","is-referenced-by-count":34,"title":["CXCL9, CXCL10, and CCL19 synergistically recruit T lymphocytes to skin in lichen planus"],"prefix":"10.1172","volume":"9","author":[{"given":"Anna E.","family":"Kersh","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Sati","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 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